219717-95-0Relevant academic research and scientific papers
Resolution of N-Protected amino alcohols by porcine pancreatic lipase
Magrioti, Victoria,Fotakopoulou, Irene,Athinaios, Nicolaos,Anastasopoulou, Panoula,Constantinou-Kokotou, Violetta,Kokotos, George
experimental part, p. 159 - 162 (2010/08/19)
The resolution of 2-amino alcohols protected by urethane-type groups either via porcine pancreatic lipase (PPL) hydrolysis of the corresponding racemic acetates or via PPL catalyzed transesterification of racemic alcohols was studied. In both cases, Boc protecting group led to better chemical yields and enantiopurities than Z and Fmoc protecting groups. Furthermore, a simple and efficient method for the synthesis of the medicinally interesting optically pure (R)-2- aminohexadecanol was developed.
Synthesis of substituted (D)-phenylalanine derivatives by regioselective reduction of enantiomerically pure cis-2,3-disubstituted aziridines
Chang, Jae-Won,Bae, Jae Hyun,Shin, Seong-Ho,Park, Chan Sun,Choi, Daeock,Lee, Won Koo
, p. 9193 - 9196 (2007/10/03)
Various N-(R)-(+)-(α-methylbenzyl)-(2R,3R)-distributed aziridines were prepared by intramolecular cyclization. The regioselective reduction of the ring C(3)-N bond in the presence of (Boc)2O by catalytic hydrogenation with atmospheric pressure of hydrogen provides (D)-phenylalaninol analogues in good yields.
