Bioorganic and Medicinal Chemistry Letters p. 2977 - 2982 (1998)
Update date:2022-07-30
Topics:
Morihira, Koichiro
Nishimori, Toshiyuki
Kusama, Hiroyuki
Horiguchi, Yoshiaki
Kuwajima, Isao
Tsuruo, Takashi
Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.
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