Synthesis and evaluation of artificial taxoids with antitumor and multi- drug resistance reversing activities

Article abstract of DOI:10.1016/S0960-894X(98)00540-X

Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.