219741-06-7

Upstream product

• 67-63-0 isopropyl alcohol 
• 219740-90-6 2,2,2-trichloro-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-N-(1,4-dioxa-spiro[4.5]dec-7-en-8-yl)-acetamide 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Relevant academic research and scientific papers

Nickel powder promoted 5-endo radical cyclisations. A concise approach to erythrina alkaloids

N-Alkenyl trichloroacetamides 3 undergo, upon refluxing with nickel powder and acetic acid in 2-propanol, exclusive 5-endo-trig cyclisation to afford functionalised lactams 4; these are attractive precursors of erythrina alkaloids, as demonstrated by the expedient synthesis of 3- demethoxyerythratidinone 5.