2198-94-9Relevant academic research and scientific papers
Synthesis of Trichoverrin B and Its Conversion to Verrucarin J
Esmond, Robert,Fraser-Reid, Bert,Jarvis, Bruce B.
, p. 3358 - 3360 (2007/10/02)
Anguidine (3b) was converted to verrucarol (3a), which in turn was selectively acylated to yield trichoverin B (2).Trichoverrin B reacts with pyridinium dichromate in dimethylformamide, via a novel oxidative ring closure, to give verrucarin J (11a) in 50 percent yield.
The ready conversion of anguidine into verrucarol and trichodermol
Tulshian, Deen Bandhu,Fraser-Reid, Bert
, p. 4549 - 4552 (2007/10/02)
Anguidine, 1, is readily converted into verrucarol diacetate, 2d, in 85 percent yield by application of the Barton-McCombie deoxygenation procedure. To enable conversion into trichodermol, 3a, the primary hydroxyl group of verrucarol, 2a, is selectively acetylated or is selectively acetylated or preferably silylated, thereby paving the way for its deoxygenation in three simple, high-yield reactions.
