219806-96-9Relevant academic research and scientific papers
Structure-activity relationships of substituted 5H-thiazolo[3,2- a]pyrimidines as group 2 metabotropic glutamate receptor antagonists
Wichmann, Juergen,Adam, Geo,Kolczewski, Sabine,Mutel, Vincent,Woltering, Thomas
, p. 1573 - 1576 (1999)
A series of 5H-thiazolo[3,2-a]pyrimidine derivatives 1 was studied with respect to the inhibition of 1S,3R-ACPD (10μM)-stimulated GTP γ35S binding on rat mGlu2 receptor transfected cell membranes. The influence of substituents at position 6 and
PHENYL-SUBSTITUTED 5H-THIAZOLO[3,2-A]PYRIMIDINE DERIVATIVE GLUTAMATE RECEPTOR ANTAGONISTS
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, (2008/06/13)
The invention is concerned with compounds of the general formula STR1 wherein R 1 is hydrogen, lower alkyl, phenyl or benzyl, R 2 is lower alkyl, lower alkoxy,--O(CH. sub.2) n N(R. sup. 13)(R 14),--(CH 2) n N(R 13)(R 14) or--N(R. sup. 15)(CH 2) n N
