Structure-activity relationships of substituted 5H-thiazolo[3,2- a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

DOI: 10.1016/S0960-894X(99)00227-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1573 - 1576 (1999)

Update date:2022-08-04

Topics:

Authors:

Wichmann, Juergen

Adam, Geo

Kolczewski, Sabine

Mutel, Vincent

Woltering, Thomas

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00227-9

A series of 5H-thiazolo[3,2-a]pyrimidine derivatives 1 was studied with respect to the inhibition of 1S,3R-ACPD (10μM)-stimulated GTP γ³⁵S binding on rat mGlu2 receptor transfected cell membranes. The influence of substituents at position 6 and

Full text of DOI:10.1016/S0960-894X(99)00227-9

Products guided by the article

Product name:2-dimethyl-amino-ethyl (RS)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate

Cas No:219806-96-9

R&D Labs maybe for 219806-96-9

Anhui Biochem United Pharmaceutical Co., Ltd.

Contact:0086 551 5167062 / 5228268

Address:No. 30 Hongfeng Road, Hi-Tech Development Zone, Hefei (230088), China
Zipont chem(wuhan）Tech co.，Ltd

Contact:+86-27-87587198

Address:wuhan
Tianjin Ji Ping Jia Chemical Co., Ltd.

Contact:18622448868

Address:tianjin
Shandong Xinhua Pharmaceutical Co.,Ltd

website:http://www.xhzy.com

Contact:+86-533-2196801

Address:1 lutai road,zhangdian dis,Zibo City
Shanxi Tongji Pharmaceuticals Co., Ltd.

Contact:+86-359-3024784

Address:Xikuang South Road, Ruicheng County , Shanxi

Relevant to this article

Short synthesis of piperidine based hexopyranose mimics. A remarkable example of syn hydrogenation

Doi:10.1016/S0040-4039(98)02313-2
(1999)
Syntheses, Structures, and Reactivity of Dinuclear Molybdenum-Platinum and Tungsten-Platinum Complexes with Bridging Carbonyl, Sulfur Dioxide, Isonitrile, and Aminocarbyne Ligands and a dppa Backbone (dppa = Ph₂PNHPPh₂)

Doi:10.1021/om980756v
(1999)
One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl- protected amines from ketones

Doi:10.1021/jo0616512
(2007)
Synthesis of enantiopure 2-aminoalkylphenols by stereoselective addition of Grignard reagents to chiral 2-imidoylphenols

Doi:10.1016/S0957-4166(02)00544-X
(2002)
IOOC route to substituted chiral pyrrolidines. Potential glycosidase inhibitors

Doi:10.1021/jo9815094
(1999)
How flexible are poly(paraphenyleneethynylene)s?

Doi:10.1002/anie.200602807
(2006)

Article Doi