Structure-activity relationships of substituted 5H-thiazolo[3,2- a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

DOI: 10.1016/S0960-894X(99)00227-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1573 - 1576 (1999)

Update date:2022-08-04

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Authors:

Wichmann, Juergen

Adam, Geo

Kolczewski, Sabine

Mutel, Vincent

Woltering, Thomas

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Article abstract of DOI:10.1016/S0960-894X(99)00227-9

A series of 5H-thiazolo[3,2-a]pyrimidine derivatives 1 was studied with respect to the inhibition of 1S,3R-ACPD (10μM)-stimulated GTP γ³⁵S binding on rat mGlu2 receptor transfected cell membranes. The influence of substituents at position 6 and

Full text of DOI:10.1016/S0960-894X(99)00227-9

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