Structure-activity relationships of substituted 5H-thiazolo[3,2- a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

DOI: 10.1016/S0960-894X(99)00227-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1573 - 1576 (1999)

Update date:2022-08-04

Topics:

Authors:

Wichmann, Juergen

Adam, Geo

Kolczewski, Sabine

Mutel, Vincent

Woltering, Thomas

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00227-9

A series of 5H-thiazolo[3,2-a]pyrimidine derivatives 1 was studied with respect to the inhibition of 1S,3R-ACPD (10μM)-stimulated GTP γ³⁵S binding on rat mGlu2 receptor transfected cell membranes. The influence of substituents at position 6 and

Full text of DOI:10.1016/S0960-894X(99)00227-9

Products guided by the article

Product name:2-dimethyl-amino-ethyl (RS)-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate

Cas No:219806-96-9

R&D Labs maybe for 219806-96-9

TIANJIN DONGRUXIANG MINERALS MARKETING CO.,LTD(expird)

Contact:22-58516360

Address:tianjin
Beijing Mashi Fine Chemical Co.,Ltd.

Contact:+86-10-61271592

Address:Room 506, Section B, Kaichi Mansion, Industrial Development
JADECHEM NINGBO CO.,LTD.

Contact:+86-574-89075960

Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
BioBioPha Co., Ltd

Contact:+86-871-65217109

Address:132 Lanhei Road, Kunming Institute of Botany, Chinese Academy of Sciences
shanghai tuomiao chemicial co.,ltd.

website:https://www.tuomiaochem.com/

Contact:021 - 59853336

Address:shanghai

Relevant to this article

Short synthesis of piperidine based hexopyranose mimics. A remarkable example of syn hydrogenation

Doi:10.1016/S0040-4039(98)02313-2
(1999)
Syntheses, Structures, and Reactivity of Dinuclear Molybdenum-Platinum and Tungsten-Platinum Complexes with Bridging Carbonyl, Sulfur Dioxide, Isonitrile, and Aminocarbyne Ligands and a dppa Backbone (dppa = Ph₂PNHPPh₂)

Doi:10.1021/om980756v
(1999)
One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl- protected amines from ketones

Doi:10.1021/jo0616512
(2007)
Synthesis of enantiopure 2-aminoalkylphenols by stereoselective addition of Grignard reagents to chiral 2-imidoylphenols

Doi:10.1016/S0957-4166(02)00544-X
(2002)
IOOC route to substituted chiral pyrrolidines. Potential glycosidase inhibitors

Doi:10.1021/jo9815094
(1999)
How flexible are poly(paraphenyleneethynylene)s?

Doi:10.1002/anie.200602807
(2006)

Article Doi