219821-37-1

Basic information

• Product Name: 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester
• Synonyms: 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester
• CAS NO: 219821-37-1
• Molecular Weight: 566.476
• Mol File: 219821-37-1.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester(219821-37-1)
• EPA Substance Registry System: 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester(219821-37-1)

Safety Data

• Hazardous Substances Data: 219821-37-1(Hazardous Substances Data)

Usage

General Description

The chemical "2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester" is a complex organic compound with a long, intricate molecular structure. It contains a hydrazinecarboxylic acid methyl ester group and various functional groups such as trifluoromethyl, phenyl, ethoxy, fluorophenyl, and morpholinyl. The compound is likely to have a wide range of chemical and biological properties due to the presence of these different groups. Its specific uses and effects would depend on the context and applications in which it is used, such as in pharmaceuticals, agrochemicals, or materials science.

Upstream product

• 171338-27-5 [2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 
• 1228018-30-1 2(R)-[1-(R)-(3,5-bis-(trifluoromethyl)phenyl)ethoxy]-3(S)-(4-fluorophenyl)morpholine oxalate 
• 155742-64-6 N-carbomethoxy-2-chloroacetamidohydrazone 
• 171482-05-6 [2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride 
• 110843-90-8 4-benzyl-morpholine-2,3-dione 
• 1185503-26-7 N-methylcarboxyl-2-chloroacetamidrazone 
• 200000-59-5 (2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate 
• 104-63-2 N-Benzylethanolamine 
• 368-63-8 (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 287930-75-0 (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one 
• 327623-36-9 (2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one 
• 502536-97-2 2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester 
• 502537-07-7 trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester 

Downstream Products

• 172822-29-6 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one 
• 170729-80-3 aprepitant 

Relevant articles and documents

Method for preparing intermediate of the Fosaprepitant

The invention discloses a method for preparing an intermediate of the Fosaprepitant, and specifically relates to a new method for preparing a drug 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazole-3-one, i.e., Aprepitant. The method comprises the steps of: synthesizing a compound (IV) in the presence of a condensation system, and then performing cyclization on the compound (IV) at 139 DEG C or below to obtain the target compound (I). The preparation method is green, environmentally friendly and efficient and has easy industrialization.

A kind of preparation method of dimethyl luck Sha Pitan cyclophosphadenosine

The invention relates to a method for preparing fosaprepitant. The fosaprepitant is shown as a formula (I). The method comprises steps 1, 2, 3 and 4, finally, a compound shown as the formula (I) is obtained through hydrogenation reduction; in the step 1, a compound in a formula (II) reacts with a Grignard reagent to generate a compound shown as a formula (III) in the presence of palladium carbon and ammonium formate. The method for preparing is simple in production step, has high reaction yield and less side products, is easy in control of the reaction conditions and is suitable for medical industrial production.

A METHOD OF PREPARING 3- ( ( (2R, 3S) -2- ( (R) -1- (3, 5 -BIS (TRIFLUOROMETHYL) PHENYL) ETHOXY) -3 - (4 - FLUOROPHENYL) MORPHOLINO) METHYL) - 1H- 1, 2, 4 -TRIAZOL- 5 (4H) -ONE (APREPITANT) IN POLYMORPH FORM I OR II

The present solution relates to a method of preparing aprepitant of formula (1) in the desired crystalline form II or I, wherein the intermediate of formula (12) is extracted with a water immiscible high-boiling solvent selected from an alcohol, ester or ketone and, after washing with water and/or brine, the solution is heated up to the boiling point of the given solvent, which results in cyclization to aprepitant, and, after cooling, the produced aprepitant is isolated.