219824-47-2

Upstream product

• 5470-84-8 4-benzyloxybutanal 
• 590-18-1 (Z)-2-Butene 

Downstream Products

• 192370-74-4 (5S,6S,7S)-10-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6-trimethyl-3-oxo-decanoic acid tert-butyl ester 
• 192370-83-5 (3S,6R,7S)-10-Benzyloxy-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6-trimethyl-5-oxo-decanoic acid tert-butyl ester 
• 192370-75-5 (3S,5S,6S,7S)-10-Benzyloxy-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6-trimethyl-decanoic acid tert-butyl ester 
• 192370-73-3 (2R,3S)-6-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylhexanal 

Relevant academic research and scientific papers

Total synthesis of brevisamide

(Figure Presented) The second total synthesis of Brevisamide, a marine cyclic ether alkaloid from Karenla brevls, is reported. This streamlined synthesis proceeds in 21 steps, 14 steps longest linear sequence, in 5.2% overall yield and features a key Sml2 reductive cyclization step to access the tetrasubstituted pyran core.

Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone a series: Some surprising observations regarding their chemical and biological properties

The title compounds have been synthesized in a convergent way by recourse to a Weiler type dianion construction.