219832-49-2 Usage
Uses
Used in Anticancer Applications:
MP-A08 is used as an anticancer agent for its ability to selectively inhibit sphingosine kinases SPHK1 and SPHK2, leading to the reduction of S1P levels and the induction of apoptosis in cancer cells. It demonstrates efficacy against a variety of human cancer cell lines and has been shown to reduce tumor vasculature, volume, and S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.
Used in Drug Delivery Systems:
While the provided materials do not specifically mention drug delivery systems for MP-A08, its potential application in this area could be explored. Given its selectivity and efficacy as an ATP-competitive inhibitor of sphingosine kinases, MP-A08 could be incorporated into novel drug delivery systems to enhance its bioavailability, targeting, and therapeutic outcomes in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 219832-49-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,8,3 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 219832-49:
(8*2)+(7*1)+(6*9)+(5*8)+(4*3)+(3*2)+(2*4)+(1*9)=152
152 % 10 = 2
So 219832-49-2 is a valid CAS Registry Number.
219832-49-2Relevant academic research and scientific papers
BENZENE SULFONAMIDE-BASED INHIBITORS OF SPHINGOSINE KINASE
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, (2016/03/13)
A novel class of sphingosine kinase (SK) inhibitor compounds are disclosed which are useful in the treatment of cancer and other proliferative cell conditions. The compounds are benzene sulfonamides with a chemical structure according to formula (I).
