219862-14-3

Basic information

• Product Name: BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
• Synonyms: BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE;(1,2,3,4-Tetrahydro-quinolin-3-yl)-carbamic acid tert-butyl ester;tert-Butyl (1,2,3,4-tetrahydroquinolin-3-yl)
• CAS NO: 219862-14-3
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.32
• Product Categories: pharmacetical
• Mol File: 219862-14-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 406.8°Cat760mmHg
• Flash Point: 199.8°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 7.9E-07mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.04±0.20(Predicted)
• CAS DataBase Reference: BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE(219862-14-3)
• EPA Substance Registry System: BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE(219862-14-3)

Safety Data

• Hazardous Substances Data: 219862-14-3(Hazardous Substances Data)

Usage

General Description

BOC-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE, also known as Boc-3-amino-THQ, is a chemical compound commonly used as a building block in organic synthesis. It consists of a tetrahydroquinoline ring with an amino group and a BOC (tert-butoxycarbonyl) protecting group. Boc-3-amino-THQ has applications in the pharmaceutical industry, particularly in the synthesis of complex molecules and drug candidates. It is known for its versatility and ability to be modified for various chemical reactions, making it a valuable tool for chemists working in drug discovery and development. Additionally, the compound has been studied for its potential biological activities, including as a potential antitumor agent.

InChI:InChI=1/C14H20N2O2/c1-14(2,3)18-13(17)16-11-8-10-6-4-5-7-12(10)15-9-11/h4-7,11,15H,8-9H2,1-3H3,(H,16,17)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 890839-20-0 tert-butyl 1-benzyl-1,2,3,4-tetrahydroquinolin-3-ylcarbamate 
• 580-17-6 3-aminoquinoline 
• 219862-13-2 3-(tert-butoxycarbonyl)aminoquinoline 

Downstream Products

• 1364165-30-9 3-(3-Methoxy-benzoylamino)-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid hydroxyamide 
• 1364165-45-6 3-(4-Chloro-benzenesulfonylamino)-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid hydroxyamide 
• 1364166-43-7 C₁₉H₂₀N₂O₄ 
• 1364166-45-9 C₁₇H₁₇ClN₂O₄S 
• 1364166-47-1 C₁₈H₁₉ClN₂O₄S 
• 1364165-58-1 3-(4-Chloro-benzenesulfonylamino)-1-methyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid hydroxyamide 
• 1266103-77-8 C₂₀H₂₂Cl₂N₂O₂ 
• 890839-20-0 tert-butyl 1-benzyl-1,2,3,4-tetrahydroquinolin-3-ylcarbamate 
• 890840-32-1 C₂₂H₂₅F₃N₂O₂ 

Relevant articles and documents

NOVEL N-HYDROXY-BENZAMIDS FOR THE TREATMENT OF CANCER

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R1 to R3 and X have the significances given herein. The present invention is also directed to proc

ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF

The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors

Tetrahydroquinoline-based small molecule inhibitors of farnesyltransferase (FT) have been identified. Lead compounds were shown to have nanomolar to sub-nanomolar activity in biochemical assays with excellent potency in a Ras-mutated cellular reversion as