851758-75-3Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors
Lombardo, Louis J.,Camuso, Amy,Clark, John,Fager, Krista,Gullo-Brown, Johnni,Hunt, John T.,Inigo, Ivan,Kan, David,Koplowitz, Barry,Lee, Francis,McGlinchey, Kelly,Qian, Ligang,Ricca, Carolyn,Rovnyak, George,Traeger, Sarah,Tokarski, John,Williams, David K.,Wu, Laurence I.,Zhao, Yufen,Manne, Veeraswamy,Bhide, Rajeev S.
, p. 1895 - 1899 (2007/10/03)
Tetrahydroquinoline-based small molecule inhibitors of farnesyltransferase (FT) have been identified. Lead compounds were shown to have nanomolar to sub-nanomolar activity in biochemical assays with excellent potency in a Ras-mutated cellular reversion as
