2199-90-8Relevant articles and documents
Facile Synthesis and Anticancer Activity Study of Novel Series of Substituted and Fused Coumarin Derivatives
Hassan,Sarg,El Deeb,Bayoumi,El Rabeb
, p. 1426 - 1443 (2018)
Various new substituted and fused coumarin analogues have been synthesized via different synthetic pathways. Among which are variable substituted coumarin derivatives bearing either biologically active side chains or rings at 5, 6, and 3 positions of the coumarin nucleus as indicated in compounds 10, 12, 13, 16–19, 21, 23–32, 38, and 42–45. In addition, different pyranocoumarin derivatives either substituted as in compounds 2, 3, and 6 or fused as compounds 33–36, pyranoxanthene analogues such as compounds 4 and 46, coumarinotriazolothiadiazine derivative 8, coumarinonaphthodiazocin analogue 39 and coumarinopyrazolone derivative 40 were synthesized. Thirty-eight of the synthesized compounds were subjected to in vitro anticancer screening against mammalian liver carcinoma HepG2 and breast carcinoma MCF7 cell lines using Cisplatin as a standard reference. The anticancer activity screening results revealed that, among the tested compounds, compounds 16, 40, and 43 bearing 4-chlorophenyl-2-aminopyridine-3-carbonitrile attached to C6 position, fused pyrazolone ring or attached to 4-chlorophenyl-2-oxo-dihydropyridine-3-carbonitrile at C3 position of the coumarin nucleus, respectively, exhibited moderate to strong activity against both cell lines.
Synthesis, characterization and antioxidant activity studies of new coumarin tethered 1,3,4-oxadiazole analogues
Achutha, Dileep Kumar,Basappa, Vagish Channa,Kariyappa, Ajay Kumar,Penubolu, Sudeep
, (2021/06/01)
The present work describes the synthesis of a series of substituted 3-(5-phenyl-1,3,4-oxadiazol-2-yl)-2H-chromen-2-ones 7(a–j) using substituted aldehydes with analogues of hydrazine hydrates by grinding technique in the presence of Iodine which helps in the cyclization process. The structures of the synthesized compounds were elucidated by spectroscopic techniques such as IR, 1H NMR, 13C NMR, and LCMS. The comparative antioxidant property (using DPPH and hydroxyl radical scavenging) has been studied with the synthesized compounds 7(a-j) and the standards. Compounds 7d and 7i show the prominent radical scavenging activity. Graphic abstract: [Figure not available: see fulltext.] Synopsis: Series of ten new coumarin-oxadiazole hybrids synthesized in three steps starting from salicylaldehyde and diethylmalonate. All new compounds were spectroscopically characterized. The results of radical scavenging activities show that, two compounds of the series 7d and 7i displayed potent DPPH and hydroxyl radical activity comparable to the standards employed, and therefore acts as antioxidant leads.
An efficient synthesis of some new coumarin hybrids endowed with expected biological activity
Abdel Atty, Hany A.,Dawood, Kamal M.,Hagaggi, Noura Sh.,Nafady, Ayman,Raslan, Mohamed A.
, p. 1579 - 1598 (2020/10/21)
Reactions of 5-bromo-2-hydroxybenzaldehyde with cyanoacetic acid hydrazide derivatives in refluxing ethanol afforded some new chromene-based polyfunctionally substituted heteroaromatics. The antimicrobial activity of some of the obtained products was eval
