219901-30-1Relevant academic research and scientific papers
Synthesis and evaluation of dual action cephalosporins as elastase inhibitors
Veinberg, Grigory,Shestakova, Irina,Petrulanis, Larisa,Grigan, Nora,Musel, Dan,Zeile, Dairis,Kanepe, Iveta,Domrachova, Ilona,Kalvinsh, Ivars,Strakovs, Andris,Lukevics, Edmunds
, p. 843 - 846 (1997)
tert-Butyl 7α-chloro- and 7α-methoxycephalosporanate 1,1-dioxides containing Aspirin and Diclofenac in their 3-acyloxymethyl moiety were synthesized. These dual action cephalosporins have been found to be potent elastase inhibitors and stimulators of NO biosynthesis in macrophages.
Synthesis and anticancer properties of 7α-chloro-3-methyl-1,1- dioxoceph-3-em-4-carboxylic acid esters
Vorona,Veinberg,Shestakova,Kanepe,Potorochina,Dikovskaya,Bokaldere,Petrova,Liepinsh,Lukevics
, p. 207 - 219 (2008/12/23)
The tert-butyl esters of 3-azidomethyl-, 3-isocyanatomethyl-, 3-chloromethyl-, and 3-p-nitrophenylvinyl-7α-chloro-1,1-dioxoceph-3-em-4- carboxylic acid, and also esters of 7α-chloro-3-methyl-1,1-dioxoceph-3-em- 4-carboxylic acid, and of 7α-chloro-3-methyl
New biological properties of tert-butyl cephalosporanate sulfones
Veinberg, Grigory,Shestakova, Irina,Grigan, Nora,Musel, Dan,Kanepe, Iveta,Domrachova, Ilona,Grigoryeva, Vera,Zharkova, Olga,Turovskis, Ivars,Kalvinsh, Ivars,Strakovs, Andris,Lukevics, Edmunds
, p. 755 - 762 (2007/10/03)
tert-Butyl cephalosporanate 1,1-dioxides variously substituted in positions 7 and 3 were obtained from 7-aminodeacetoxycephalosporanic acid (7- ADCA) and 7-aminocephalosporanic acid (7-ACA). It was found that the cephalosporins containing Aspirin and Diclofenac in a prodrug form in their 3-acyloxymethyl moiety release them after hydrolytic splitting of the β- lactam ring. They also demonstrated high efficacy as elastase inhibitors. Two of them stimulated the biosynthesis of nitric oxide in RAW 264.7 macrophages cells. The same effect observed in tumor and normal cells in the presence of cephalosporins was accompanied by cytotoxic effect in vitro.
