Synthesis and evaluation of dual action cephalosporins as elastase inhibitors

DOI: 10.1016/S0960-894X(97)00104-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 843 - 846 (1997)

Update date:2022-08-11

Topics:

Authors:

Veinberg, Grigory

Shestakova, Irina

Petrulanis, Larisa

Grigan, Nora

Musel, Dan

Zeile, Dairis

Kanepe, Iveta

Domrachova, Ilona

Kalvinsh, Ivars

Strakovs, Andris

Lukevics, Edmunds

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Article abstract of DOI:10.1016/S0960-894X(97)00104-2

tert-Butyl 7α-chloro- and 7α-methoxycephalosporanate 1,1-dioxides containing Aspirin and Diclofenac in their 3-acyloxymethyl moiety were synthesized. These dual action cephalosporins have been found to be potent elastase inhibitors and stimulators of NO biosynthesis in macrophages.

Full text of DOI:10.1016/S0960-894X(97)00104-2

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