Synthesis and evaluation of dual action cephalosporins as elastase inhibitors

Article abstract of DOI:10.1016/S0960-894X(97)00104-2

tert-Butyl 7α-chloro- and 7α-methoxycephalosporanate 1,1-dioxides containing Aspirin and Diclofenac in their 3-acyloxymethyl moiety were synthesized. These dual action cephalosporins have been found to be potent elastase inhibitors and stimulators of NO biosynthesis in macrophages.