Bioorganic and Medicinal Chemistry Letters p. 843 - 846 (1997)
Update date:2022-08-11
Topics:
Veinberg, Grigory
Shestakova, Irina
Petrulanis, Larisa
Grigan, Nora
Musel, Dan
Zeile, Dairis
Kanepe, Iveta
Domrachova, Ilona
Kalvinsh, Ivars
Strakovs, Andris
Lukevics, Edmunds
tert-Butyl 7α-chloro- and 7α-methoxycephalosporanate 1,1-dioxides containing Aspirin and Diclofenac in their 3-acyloxymethyl moiety were synthesized. These dual action cephalosporins have been found to be potent elastase inhibitors and stimulators of NO biosynthesis in macrophages.
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