219993-45-0Relevant academic research and scientific papers
Novel and efficient synthesis of spirocyclic morpholinones as precursors of ψ[CH2O] dipeptide isosteres
Fritch, Paul C.,Kazmierski, Wieslaw M.
, p. 112 - 116 (2007/10/03)
A series of novel dipeptide mimetics 4, featuring replacement of peptide bond by ψ[CH2O], was synthesized in high yields from their precursors, novel spirocyclic morpholinones 2. Efficient and reliable chemistry leading to 2 was accomplished by alkylating morpholinone 1 with 1-chloro-ω- iodoalkanes, followed by Finkelstein iodide exchange and LDA-mediated intramolecular spirocyclization.
