220041-91-8

Upstream product

• 90319-52-1 (4R)-phenyl-2-oxazolidinone 
• 501-52-0 3-Phenylpropionic acid 
• 124-38-9 carbon dioxide 
• 155835-37-3 (4R)-3-(3-phenyl-2-(E)-propenoyl)-4-phenyl-2-oxazolidinone 
• 56613-80-0 D-2-phenylglycinol 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 1314751-88-6 ethyl 2-((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetate hydrochloride 
• 1314751-83-1 ethyl N-[(2S)-2-benzyl-3-hydroxypropanoyl]glycinate 
• 156053-89-3 Entereg 
• 147383-72-0 (S)-2-hydroxymethyl-3-phenylpropionic acid 
• 1337489-13-0 (2R)-2-benzyl-3,3,3-trifluoropropanoic acid 
• 1335544-67-6 (4R)-3-[(2R)-2-benzyl-3,3,3-trifluoropropanoyl]-4-phenyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Stereoselective electrochemical carboxylation: 2-phenylsuccinates from chiral cinnamic acid derivatives

Chiral 2-phenyl succinic ester derivatives have been obtained under mild conditions, in short times and with satisfactory yields by electrochemical reduction of chiral cinnamic acid derivatives under a CO2 atmosphere. When 4R-(diphenylmethyl)-o

Diastereoselective Electrophilic Trifluoromethylthiolation of Chiral Oxazolidinones: Access to Enantiopure α-SCF3 Alcohols

Lithium imide enolates featuring Evans’ chiral oxazolidinone auxiliary were involved in diastereoselective α-trifluoromethylthiolation with electrophilic SCF3 donors. Diastereopure products were isolated and converted to enantiopure α-SCF3 alcohols without racemisation. (Figure presented.).

IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXYPHENYL)-3(R),4-DIMETHYL-1-PIPERIDINYL]METHYL]-1-OXO-3-PHENYLPROPYL]AMINO]ACETIC ACID DIHYDRATE

The present invention relates to an improved process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate, represented by the following structural formula (I).

Synthesis of α-CF3-substituted carbonyl compounds with relative and absolute stereocontrol using electrophilic CF3-transfer reagents

Evans-type chiral lithium imide enolates undergo diastereoselective α-trifluoromethylation with a hypervalent iodine-CF3 reagent with up to 91% combined isolated yield and 97:3 dr. The resulting isolated diastereopure products can be further transformed into valuable products without racemization.

Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones. 2

An improved and efficient electrochemical N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of Me

4-ferrocenyl-1,3-oxazoline derivatives as ligands for catalytic asymmetric allylation reactions

Bis(oxazolines) and 2-(2-phosphinoaryl)oxazolines derived from highly enantiopure 2-amino-2-ferrocenylethanol have been tested as ligands in the asymmetric Pd(0)-catalysed allylic alkylation reaction. Essentially complete enantioselectivity (99.8:0.2 er) has been achieved in the nucleophilic substitution of 1,3-diphenyl-2-propenyl acetate by dimethyl malonate anion. The absolute configuration of the ligands has been unambiguously established by chiroptical methods.

A convenient and practical method for N-acylation of 2 oxazolidinone chiral auxiliaries with acids

A one-pot, convenient and practical method for N-acylation of 2- oxazolidinone chiral auxiliaries directly with acids in the presence of pivaloyl chloride and triethylamine is described.