220061-72-3

Basic information

• Product Name: (4,4-dimethoxy-cyclohexyloxymethyl)-benzene
• Synonyms: (4,4-dimethoxy-cyclohexyloxymethyl)-benzene
• CAS NO: 220061-72-3
• Molecular Weight: 250.338
• Mol File: 220061-72-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4,4-dimethoxy-cyclohexyloxymethyl)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (4,4-dimethoxy-cyclohexyloxymethyl)-benzene(220061-72-3)
• EPA Substance Registry System: (4,4-dimethoxy-cyclohexyloxymethyl)-benzene(220061-72-3)

Safety Data

• Hazardous Substances Data: 220061-72-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 2987-06-6 4-(benzyloxy)cyclohexanone 
• 149-73-5 trimethyl orthoformate 
• 100-39-0 benzyl bromide 
• 556-48-9 1,4-Cyclohexanediol 
• 2976-80-9 4-(benzyloxy)cyclohexan-1-ol 

Downstream Products

• 1202462-44-9 1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-methoxy-cyclohexyl]-propylamine 
• 1202462-45-0 1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-methoxy-cyclohexyl]-propylamine 
• 1202462-42-7 1-(4-benzyloxy-1-methoxy-cyclohexyl)-propylamine 
• 1202462-43-8 4-(1-amino-propyl)-4-methoxy-cyclohexanol 
• 906318-14-7 4-benzyloxy-1-methoxy-cyclohexanecarbonitrile 
• 906318-02-3 1-(4-benzyloxy-1-methoxy-cyclohexyl)-3-methyl-butan-2-one 
• 906318-24-9 4-methoxy-4-propyl-cyclohexanol 
• 906318-01-2 [4-Methoxy-4-(3-methyl-2-methylene-butyl)-cyclohexyloxymethyl]-benzene 
• 906318-29-4 4-ethyl-4-methoxy-cyclohexanol 

Relevant articles and documents

Development and Mechanistic Studies of the Iridium-Catalyzed C?H Alkenylation of Enamides with Vinyl Acetates: A Versatile Approach for Ketone Functionalization

Ketone functionalization is a cornerstone of organic synthesis. Herein, we describe the development of an intermolecular C?H alkenylation of enamides with the feedstock chemical vinyl acetate to access diverse functionalized ketones. Enamides derived from various cyclic and acyclic ketones reacted efficiently, and a number of sensitive functional groups were tolerated. In this iridium-catalyzed transformation, two structurally and electronically similar alkenes—enamide and vinyl acetate—underwent selective cross-coupling through C?H activation. No reaction partner was used in large excess. The reaction is also pH- and redox-neutral with HOAc as the only stoichiometric by-product. Detailed experimental and computational studies revealed a reaction mechanism involving 1,2-Ir-C migratory insertion followed by syn-β-acetoxy elimination, which is different from that of previous vinyl acetate mediated C?H activation reactions. Finally, the alkenylation product can serve as a versatile intermediate to deliver a variety of structurally modified ketones.

Electrostatic effects on the reactions of cyclohexanone oxocarbenium ions

Nucleophilic substitution reactions of 4-substituted cyclohexanone acetals display different selectivities depending upon the electronic nature of the substituent. Alkyl groups favor equatorial positions in the oxocarbenium ions, but alkoxy groups prefer