220080-46-6

Upstream product

• 219814-64-9 methyl (5-acetamido-4,7,8-tri-O-acetyl-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-2-nonulopyranoso)onate 
• 219814-61-6 allyl 2-acetamido-3,4-di-O-acetyl-6-azido-2-deoxy-β-D-glucopyranoside 
• 151895-54-4 allyl 2-acetamido-3,4-di-O-acetyl-2-deoxy-6-O-p-tolylsulfonyl-β-D-glucopyranoside 
• 63064-48-2 allyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranoside 
• 54400-75-8 allyl 2-acetamido-2-deoxy-β-D-glucopyranoside 
• 155155-64-9 (4S,5R,6R)-4-Acetoxy-5-acetylamino-2-phenylsulfanyl-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 220080-45-5 (4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-phenylsulfanyl-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 219814-65-0 methyl (phenyl 5-acetamido-4,7,8-tri-O-acetyl-9-azido-2-thio-3,5,9-trideoxy-D-glycero-β-D-galacto-2-nonulopyranosid)onate 

Relevant academic research and scientific papers

Chemoenzymatic synthesis of an N-acetylneuraminic acid analogue having a carbamoylmethyl group at C-4 as an inhibitor of sialidase from influenza virus

5,9-Diacetamido-2,6-anhydro-O-4-carbamoylmethyl-3,5,9-trideoxy-d-glycero-d-galacto-non-2-enonic acid (1) was synthesized via a key intermediate 2 through the Neu5Ac aldolase [E.C.4.1.3.3]-catalyzed aldol reaction of 2-acetamido-2,6-dideoxy-6-azido-d-glucose with sodium pyruvate operating under alkaline conditions (pH 10.5) in order to accelerate epimerization C-2 of N-acetyl-d-glucosamine (d-GlcNAc) derivatives. Compound 1 showed inhibitory activity against sialidase. Copyright (C) 1998 Elsevier Science Ltd.

Synthesis of immobilized CMP-sialic acids and their enzymatic transfer with sialyltransferase

A novel immobilization procedure for glycoproteins is based on the reaction of immobilized CMP-NeuAc (CMP-sialic acids) with sialyltransferase (see scheme). The transfer ability was tested under various conditions; a corresponding oligosaccharide or asial