220156-99-0Relevant articles and documents
Folic acid targeting porphin photosensitizer coupled by different connecting chains and synthesis and application of folic acid targeting porphin photosensitizer
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Paragraph 0131; 0134-0135, (2020/12/15)
The invention relates to a folic acid targeting porphin photosensitizer coupled by different connecting chains and synthesis and application thereof, and discloses a photosensitizer as shown in a general formula (I), a preparation method of the photosensitizer and an application of the photosensitizer in tumor photodynamic therapy and tumor imaging diagnosis. In the photosensitizer, folic acid, which is a tumor-targeting ligand, is linked to a porphin-type photosensitive moiety via different chain lengths of linking moieties optionally having an acidic amino acid fragment. A-Lys-(L)m-(B)o-C(I)is shown in the specification.
A MedChem toolbox for cereblon-directed PROTACs
Steinebach, Christian,Sosi?, Izidor,Lindner, Stefanie,Bricelj, Ale?a,Kohl, Franziska,Ng, Yuen Lam Dora,Monschke, Marius,Wagner, Karl G.,Kr?nke, Jan,Gütschow, Michael
supporting information, p. 1037 - 1041 (2019/06/27)
A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.
Multivalent Siderophore–DOTAM Conjugates as Theranostics for Imaging and Treatment of Bacterial Infections
Ferreira, Kevin,Hu, Hai-Yu,Fetz, Verena,Prochnow, Hans,Rais, Bushra,Müller, Peter P.,Br?nstrup, Mark
supporting information, p. 8272 - 8276 (2017/06/30)
There is a strong need to better diagnose infections at deep body sites through noninvasive molecular imaging methods. Herein, we describe the synthesis and characterization of probes based on siderophore conjugates with catechol moieties and a central DO
1,4,7,10-TETRAZACYCLODODECANE BASED AGENTS TO TARGET BACTERIA AND ITS USE
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Page/Page column 20, (2016/03/18)
The present invention relates to new compounds comprising a siderophore moiety as well as a core structure able to chelate a metal ion. Optionally, the compounds may have additionally a moiety with a functional element including a marker molecule, a bioactive agent, an activity based probe suitable to monitor the aberrant expression or activity of proteins involved in the initiation and progression of bacterial infection, or a compound useful for bacterial inhibition. In a further aspect, the present invention provides a pharmaceutical composition containing said compound, for example, said pharmaceutical composition is an antibiotic. Additionally, the present invention relates to the use of said compounds in diagnostic methods, in particular, imaging methods including SPEC, PET or MRI. In an embodiment of the present invention, the compound is part of a theranostic composition having both, therapeutic as well as diagnostic activities.
TAGGABLE HETEROAROMATIC DRUGS AND CONJUGATES THEREOF
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Paragraph 0093; 00120, (2017/01/02)
The present invention provides heteroarene-based drag derivatives having a "clickable" ketone group, as well as conjugates of said drug derivatives with targeting moieties capable of binding to extracellular antigens; and pharmaceutical compositions compr
Controlling multivalency and multimodality: Up to pentamodal dendritic platforms based on diethylenetriaminepentaacetic acid cores
Pulido, Daniel,Albericio, Fernando,Royo, Miriam
supporting information, p. 1318 - 1321 (2014/04/03)
A highly versatile synthetic strategy is described to generate multimodal and multivalent platforms based on a diethylenetriaminepentaacetic (DTPA) core. Compounds with different functionalization patterns, from mono- to pentamodal, have been prepared using robust and simple chemistry.
REPROGRAMMING UROKINASE INTO AN ANTIBODY-RECRUITING ANTICANCER AGENT
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Page/Page column 13; 62; 63, (2013/05/23)
The present invention relates to chimeric (preferably, bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including metastatic cancer where cancer cells exhibit ovrexpression
SIMULTANEOUS IMAGING OF CARDIAC PERFUSION AND A VITRONECTIN RECEPTOR TARGETED IMAGING AGENT
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, (2008/06/13)
The present invention describes a method of concurrent imaging in a mammal comprising: a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and b) concurrently detecting the vitronectin receptor targ
REMEDIES FOR JOINT DISEASES BOUND TO HYALURONIC ACID
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, (2008/06/13)
The object of the present invention is to provide a conjugate of a therapeutic agent for joint diseases and hyaluronic acid, a hyaluronic acid derivative or a salt thereof which can retain the therapeutic agent for joint diseases in joint cavities. Accord
Indazole vitronectin receptor antagonist pharmaceuticals
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, (2008/06/13)
The present invention d ribs novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present in
