916585-44-9

Upstream product

• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 220156-99-0 benzyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate 
• 4480-83-5 1,4-dioxane-2,6-dione 
• 308241-31-8 9H-fluoren-9-ylmethyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate 
• 4246-51-9 4,7,10-trioxa-1,13-diaminotridecane 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Downstream Products

• 1228150-81-9 C₆₀H₈₈N₁₆O₁₉ 
• 1228150-81-9 DTPA-PEGO-MSH⁽⁴⁾ 

Relevant academic research and scientific papers

Synthesis of versatile chemical tools toward a structure/properties relationships study onto targeting colloids

As part of a drug delivery project, four aldehydes of the type Pam-Lys(Pam)-spacer-CO-CHO were synthesized to be included in targeting colloids. Though amphiphilic, they were obtained within reasonable yields (18-55%) and with high RP-HPLC purity (～90%). Parallely, six complementary targeting peptides of the type H2N-NH-CH2-CO-spacer-YGRGDSP-NH2 were prepared to be anchored onto colloids. Isolated yields are related to the spacer length and nature. To easily and rapidly modulate the distance between the peptide and the vesicle, every partners were elaborated on solid phase and the expected constructions were obtained by hydrazone ligation. One possible application is presented here with multilamellar vesicles targeting HUVEC cells. Preliminary results prove that the fine-tuning of the spacer length permits to optimize the recognition toward the target cells.

Folic acid targeting porphin photosensitizer coupled by different connecting chains and synthesis and application of folic acid targeting porphin photosensitizer

The invention relates to a folic acid targeting porphin photosensitizer coupled by different connecting chains and synthesis and application thereof, and discloses a photosensitizer as shown in a general formula (I), a preparation method of the photosensitizer and an application of the photosensitizer in tumor photodynamic therapy and tumor imaging diagnosis. In the photosensitizer, folic acid, which is a tumor-targeting ligand, is linked to a porphin-type photosensitive moiety via different chain lengths of linking moieties optionally having an acidic amino acid fragment. A-Lys-(L)m-(B)o-C(I)is shown in the specification.

AMINO DIACIDS CONTAINING PEPTIDE MODIFIERS

The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula 1 in the synthesis of peptide derivatives.