220162-68-5Relevant academic research and scientific papers
Spirocyclohexadienones. 6. Three-component synthesis of 1-R-3,3-dimethyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones
Glushkov, V. A.,Ausheva, O. G.,Shurov, S. N.,Shklyaev, Yu. V.
, p. 894 - 896 (2002)
1-R-3,3-Dimethyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones were synthesized through three-component condensation of anisole, isobutyraldehyde, and a corresponding nitrile in dichloromethane in the presence of concentrated sulfuric acid.
Synthesis of 1-substituted 2-azaspiro[4.5]deca-6,9-diene-8-ones and 2-azaspiro[4.5]deca-1,6,9-triene-8-ones by a three-component condensation of 1,2,3-, 1,2,4- or 1,3,5-trimethoxybenzene with isobutyric aldehyde and nitriles
Glushkov, Vladimir A.,Stryapunina, Olga G.,Gorbunov, Alexey A.,Maiorova, Olga A.,Slepukhin, Pavel A.,Ryabukhina, Sandra Ya.,Khorosheva, Elena V.,Sokol, Valentina I.,Shklyaev, Yurii V.
experimental part, p. 721 - 729 (2010/09/10)
A three-component condensation of 1,2,3- or 1,2,4-trimethoxybenzene with isobutyric aldehyde and alkyl cyanoacetates in the presence of sulfuric acid resulted in the formation of substituted 2-azaspiro[4.5]deca-6,9-diene-8-ones. The same reaction of aromatic nitriles yielded 2-azaspiro[4.5]deca-1,6,9-triene-8-ones; in the case of 1,2,3-trimethoxybenzene corresponding Ritter amides were also observed. The condensation of 1,3,5-trimethoxybenzene with isobutyric aldehyde and alkyl cyanoacetates provided the compounds of the formal Kn?evenagel condensation.
