220184-57-6Relevant academic research and scientific papers
Catalytic asymmetric Strecker synthesis. Preparation of enantiomerically pure α-amino acid derivatives from aldimines and tributyltin cyanide or achiral aldehydes, amines, and hydrogen cyanide using a chiral zirconium catalyst
Ishitani, Haruro,Komiyama, Susumu,Hasegawa, Yoshiki,Kobayashi, Shu
, p. 762 - 766 (2007/10/03)
Catalytic enantioselective Strecker-type reactions of aldimines with tributyltin cyanide (Bu3SnCN) proceeded smoothly in the presence of a novel chiral zirconium catalyst. High levels of enantioselectivities in the synthesis of α-amino nitrile
Catalytic, enantioselective synthesis of α-aminonitriles with a novel zirconium catalyst
Ishitani, Haruro,Komiyama, Susumu,Kobayashi, Shu
, p. 3186 - 3188 (2007/10/03)
Strecker reactions of aldimines with Bu3SnCN in the presence of the novel chiral zirconium binuclear catalyst 1 provide α-aminonitriles in good yields and with high enantioselectivities. The reaction can be applied to a wide range of substrates. Since both enantiomers of the choral sources are readily available, both enantiomers of the α-aminonitriles are easily prepared according to this method. L = N-methylimidazole.
