220200-89-5

Upstream product

• 147-85-3 L-proline 
• 100-39-0 benzyl bromide 
• 118916-60-2 (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one 

Downstream Products

• 869001-84-3 methyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolinate 
• 869001-92-3 N-tert-butyloxycarbonyl-glycyl-L-2-benzylproline 
• 869002-01-7 di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate 
• 706806-60-2 (R)-2-benzyl-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 1163707-12-7 (R)-2-benzyl-pyrrolidine-2-carboxylic acid amide 

Relevant academic research and scientific papers

Synthesis of proline-modified analogues of the neuroprotective agent glycyl-L-prolyl-glutamic acid (GPE)

The synthesis of ten proline-modified analogues of the neuroprotective tripeptide GPE is described. Five of the analogues incorporate a proline residue with a hydrophobic group at C-2 and two further analogues have this side chain locked into a spirolactam ring system. The pyrrolidine ring was also modified by replacing the γ-CH2 group with sulfur and/or incorporation of two methyl groups at C-5.

Preparation method of (R)-1-alkanoyl-2-substituted pyrrolidine-2-formamide and medicinal application of (R)-1-alkanoyl-2-substituted pyrrolidine-2-formamide

The invention discloses (R)-1-alkanoyl-2-substituted pyrrolidine-2-formamide as shown in a general formula (I), a preparation method of a compound, a new application of the compound and a pharmaceutical composition containing the compound in the aspect of inhibiting neuroglial cell inflammation.

ANALOGS OF GLYCYL-PROLYL-GLUTAMATE

Embodiments of this invention include novel analogs of Glycyl-Prolyl-Glutamate (GPE) and compositions containing such analogs of GPE. Of these, certain analogs have modified proline residues. Other embodiments of this invention include uses of analogs of GPE to protect neural cells from degeneration and/or death in response to injury or disease. Disorders treatable with compounds and compositions of this invention include hypoxia/ischemia, toxic injury, and chronic neurodegenerative disorders including Parkinson''s disease.

4-Alkyl-2-trichloromethyloxazolidin-5-ones: Valuable precursors to enantiomerically pure C- and N-protected α-alkyl prolines

An efficient, economical and enantioselective method for preparation of various mono-and diprotected α-substituted proline derivatives is described. The lithium enolate of known 2-trichloromethyloxazolidin-5-one 3b reacted with electrophiles to furnish th