220210-24-2Relevant academic research and scientific papers
Synthesis of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties
Takahashi, Takashi,Tanaka, Hiroshi,Matsuda, Akihisa,Doi, Takayuki,Yamada, Haruo
, p. 3299 - 3302 (1998)
Syntheses of hybrid DNA cleaving molecules which have the 9-membered enediyne structure of kedarcidin with the DNA intercalator of NCS and/or the sugar moieties were accomplished. Introduction of the sugar moieties to the masked enediyne was achieved via S-alkylation of a bromoacetate derivative with a sugar-containing thiol without the need for protection of the sugar moiety.
