Bioorganic and Medicinal Chemistry Letters p. 3299 - 3302 (1998)
Update date:2022-09-26
Topics:
Takahashi, Takashi
Tanaka, Hiroshi
Matsuda, Akihisa
Doi, Takayuki
Yamada, Haruo
Syntheses of hybrid DNA cleaving molecules which have the 9-membered enediyne structure of kedarcidin with the DNA intercalator of NCS and/or the sugar moieties were accomplished. Introduction of the sugar moieties to the masked enediyne was achieved via S-alkylation of a bromoacetate derivative with a sugar-containing thiol without the need for protection of the sugar moiety.
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