161622-16-8

Basic information

• Product Name: methyl 4-cyclopentyl-3-(trifluoromethyl)benzoate
• Synonyms: methyl 4-cyclopentyl-3-(trifluoromethyl)benzoate
• CAS NO: 161622-16-8
• Molecular Weight: 272.267
• Mol File: 161622-16-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 4-cyclopentyl-3-(trifluoromethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-cyclopentyl-3-(trifluoromethyl)benzoate(161622-16-8)
• EPA Substance Registry System: methyl 4-cyclopentyl-3-(trifluoromethyl)benzoate(161622-16-8)

Safety Data

• Hazardous Substances Data: 161622-16-8(Hazardous Substances Data)

Upstream product

• 115933-50-1 methyl 4-hydroxy-3-(trifluoromethyl)benzoate 
• 220239-68-9 4-hydroxy-3-(trifluoromethyl)benzoic acid 
• 956904-10-2 4-trifluoromethanesulfonyloxy-3-trifluoromethylbenzoic acid methyl ester 
• 1737-36-6 4-chloro-3-(trifluoromethyl)benzoic acid 
• 32916-51-1 cyclopentylmagnesium chloride 
• 115591-64-5 4-chloro-3-trifluoromethylbenzoic acid methyl ester 

Downstream Products

• 957205-39-9 (4-cyclopentyl-3-(trifluoromethyl)phenyl)methanol 
• 957208-65-0 4-(chloromethyl)-1-cyclopentyl-2-(trifluoromethyl)benzene 
• 1206124-34-6 (R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate 
• 1206123-37-6 [(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid 
• 1206123-97-8 (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid, L-arginine salt 
• 1206123-55-8 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid 

Relevant articles and documents

AROMATIC RING DERIVATIVE AS IMMUNOREGULATION AND PREPARATION METHOD AND APPLICATION OF AROMATIC RING DERIVATIVE

Relating to a compound represented by formula (I) and a pharmaceutically acceptable salt of the compound, and an application of the compound as an S1P1 agonist.

Discovery of APD334: Design of a clinical stage functional antagonist of the sphingosine-1-phosphate-1 receptor

APD334 was discovered as part of our internal effort to identify potent, centrally available, functional antagonists of the S1P1 receptor for use as next generation therapeutics for treating multiple sclerosis (MS) and other autoimmune diseases

SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.