220243-56-1 Usage
Uses
Used in Organic Synthesis:
TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-4-(OXIRAN-2-YL)BUTANOATE is used as a reagent for the synthesis of complex organic molecules, leveraging its Boc protecting group to prevent unwanted reactions during the process.
Used in Peptide Synthesis:
In the field of peptide synthesis, TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-4-(OXIRAN-2-YL)BUTANOATE is utilized as a protecting group for the amine functionality of amino acids, ensuring selective reactions and facilitating the stepwise assembly of peptide chains.
Used in Pharmaceutical Compound Production:
TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-4-(OXIRAN-2-YL)BUTANOATE is employed in the production of pharmaceutical compounds, where its oxiran-2-yl group allows for the introduction of different functional groups, enhancing the compound's therapeutic potential.
Used in the Pharmaceutical Industry:
TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-4-(OXIRAN-2-YL)BUTANOATE is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its versatility in protecting amine groups and facilitating the introduction of functional groups makes it an essential component in the creation of novel medicinal compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 220243-56-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,2,4 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 220243-56:
(8*2)+(7*2)+(6*0)+(5*2)+(4*4)+(3*3)+(2*5)+(1*6)=81
81 % 10 = 1
So 220243-56-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H27NO5/c1-14(2,3)20-12(17)11(8-7-10-9-19-10)16-13(18)21-15(4,5)6/h10-11H,7-9H2,1-6H3,(H,16,18)
220243-56-1Relevant academic research and scientific papers
Pyridine derivatives
-
, (2008/06/13)
The invention relates to a process for producing pyridinoline and deoxypyridinoline crosslinks and derivatives thereof and their use in determining connective tissue disorders in humans and animals.
Collagen cross-links: Synthesis of pyridinoline, deoxypyridinoline and their analogues
Adamczyk, Maciej,Johnson, Donald D.,Reddy, Rajarathnam E.
, p. 63 - 88 (2007/10/03)
An efficient chiral synthesis of (S,S)-(-)-3g, a key intermediate for the preparation of collagen cross-links pyridinoline (Pyd, 1) and deoxypyridinoline (Dpd, 2) was achieved from (4S)-5(tert-butoxy)-4-[(tert- butoxycarbonyl)amino]-5-oxopentanoic acid (21b). Quaternization of (S,S)-(- )-3g with iodide (2S, 5R)-(+)-4a followed by hydrolysiS provided a first chiral synthesis of natural (+)-Pyd (1). 1-(2S)-(+)-Pyd (1) was also synthesized from (S,S)-(-)-3g and iodide (2S, 5S)-(+)-4a. Similarly, quaternization of (S,S)-(-)-3g with iodide (2S)-(-)-4b, which was prepared from (2S)-(-)-6-amino-2[(tert-butoxycarbonyl)amino]hexanoic acid (31) in three steps, followed by hydrolysis afforded natural (+)-Dpd (2) in 5.3% overall yield. Also, the synthesis of racemic Dpd [(±)-2] and a variety of its analogues is presented.
