220293-41-4

Upstream product

• 67-56-1 methanol 
• 220293-36-7 (5-chloro-4-methyl-2-sulfamoyl-phenylsulfanyl)-phenyl-acetic acid 
• 4870-65-9 2-bromophenylacetic acid 
• 95792-62-4 4-chloro-2-mercapto-5-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Syntheses of S,N-substituted 2-mercaptobenzenesulfonamide derivatives with potential pharmacological activity

A series of [5-chloro-4-methyl-2-sulfamoylphenyl(thio or sulfonyl)]alkanoic acids [I-VI], their methyl esters [VII-XII] and hydrazides [XIII-XXI] were prepared. The treatment of the selected esters [VII-VIII, XI-XII] with appropriate biguanide hydrochlorides gave 4-chloro-5-methyl-2-[2-amino-6-R3-triazin-4-ylalkyl(thio or sulfonyl)]benzenesulfonamides [XXII-XXVII]. The anticancer activity was observed in vitro for compound [XXII].