4870-65-9Relevant articles and documents
MALIC ENZYME INHIBITORS
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Page/Page column 119, (2021/04/23)
The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.
A metal-free and mild approach to 1,3,4-oxadiazol-2(3: H)-ones via oxidative C-C bond cleavage using molecular oxygen
Lim, Bumhee,Park, Seunggun,Park, Jae Hyun,Gam, Jongsik,Kim, Sanghee,Yang, Jung Woon,Lee, Jeeyeon
supporting information, p. 2105 - 2113 (2018/03/26)
A mild metal-free approach to 1,3,4-oxadiazol-2(3H)-ones via 1,3,4-oxadiazin-5(6H)-ones is described. This novel transformation, promoted by the electron-withdrawing p-substituents on the phenyl group at the α-carbonyl position, features a tandem reaction consisting of oxidative hydroxylation and C-C bond cleavage using molecular oxygen. The method utilizes K2CO3 in CH3CN without any oxidants, transition metals, or additives, enabling the tunable synthesis of 1,3,4-oxadiazin-5(6H)-ones, 1,3,4-oxadiazol-2(3H)-ones, and α-ketoamides under mild aerobic conditions.
Thiazolidinedione chemical compound preparation method
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Paragraph 0014, (2016/10/07)
The present invention discloses a new thiazolidinedione chemical compound preparation method. The synthetic route is shown in the description wherein R1 and R2 are H, CH3, MeO or t-Bu. The thiazolidinedione chemical compound synthesized by the new method is high in solubility and reactivity. Currently, such method has not yet been reported in the literature. The new method has the following advantages: the method is wide in applicability, short in reaction path, high in reaction efficiency, simple in after-treatment, low in cost, and suitable for industrial production.