220378-07-4

Upstream product

• 220378-02-9 tert-butyl (1-((((4-chlorobenzyl)amino)sulfonyl)methyl)-5-(1-(triphenylmethyl) imidazol-4-yl)pentyl) carbonate 
• 204857-35-2 N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide 
• 104-86-9 4-chlorobenzylamine 
• 42060-30-0 N-(4-chloro-benzyl)-methanesulfonamide 

Relevant academic research and scientific papers

1H-4(5)-substituted imidazole derivatives, their preparation and their use as histamine H3 receptor ligands

A compound of the formula wherein R2is an optionally substituted Czto Cgalkylene or alkylene chain; R3is C2to C15optionally substituted hydrocarbyl; X is a bond or —NR4—, wherein

ω-(Imidazol-4-yl)alkane-1-sulfonamides: a new series of potent histamine H3 receptor antagonists

ω-(1H-Imidazol-4-yl)alkane-1-sulfonamides were prepared and found to be potent histamine H3 receptor antagonists. High receptor affinity and a low difference in the data between the bioassays were achieved with 5-(1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide (16). Good in vitro profiles were also obtained for 2-hydroxysulfonamide and vinylsulfonamide analogues. This complements and completes the existing set of imidazole-based sulfonamides and sulfamides. Copyright