22041-23-2Relevant academic research and scientific papers
Formulation optimization of an ephrin A2 targeted immunoliposome encapsulating reversibly modified taxane prodrugs
Huang, Zhaohua Richard,Tipparaju, Suresh Kumar,Kirpotin, Dmitri B.,Pien, Christine,Kornaga, Tad,Noble, Charles O.,Koshkaryev, Alexander,Tran, Jimmy,Kamoun, Walid S.,Drummond, Daryl C.
, p. 47 - 57 (2019/08/20)
Ephrin A2 targeted immunoliposomes incorporating pH-sensitive taxane prodrugs were developed for sustained delivery of active drug to solid tumors. Here we describe the systematic formulation development and characterization of these immunoliposomes. We s
AMPHOTERIC BETAINE COMPOUNDS
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Paragraph 0081-0085, (2017/04/11)
Disclosed are a variety of amphoteric compounds containing a quaternary nitrogen group, a covalently bound counterion, and an ester or amide group. These amphoteric compounds can be advantageously prepared via a chemoenzymatic green process, and exhibit good surfactant properties.
Targeting carnitine biosynthesis: Discovery of new inhibitors against γ-butyrobetaine hydroxylase
Tars, Kaspars,Leitans, Janis,Kazaks, Andris,Zelencova, Diana,Liepinsh, Edgars,Kuka, Janis,Makrecka, Marina,Lola, Daina,Andrianovs, Viktors,Gustina, Daina,Grinberga, Solveiga,Liepinsh, Edvards,Kalvinsh, Ivars,Dambrova, Maija,Loza, Einars,Pugovics, Osvalds
, p. 2213 - 2236 (2014/04/17)
γ-Butyrobetaine hydroxylase (BBOX) catalyzes the conversion of gamma butyrobetaine (GBB) to l-carnitine, which is involved in the generation of metabolic energy from long-chain fatty acids. BBOX inhibitor 3-(1,1,1-trimethylhydrazin-1-ium-2-yl)propanoate (
Synthesis of benzoic acids and polybenzamides containing tertiary alkylamino functionality
Khan, Gul Shahzada,Dickson, Benjamin D.,Barker, David
scheme or table, p. 1790 - 1801 (2012/03/11)
The high-yielding and easily scalable synthesis of a number of benzoic acids bearing a tertiary alkylamino functionality has been achieved. The flexible synthesis began from readily available aminobenzoic acids or terephthaloyl chloride and requires almost no chromatography. Coupling of the synthesised amino acids to a range of substituted anilines was achieved when utilizing a specific combination of DIC, HOBt and DMAP.
4-[(HALOALKYL)(DIMETHYL)AMMONIO]BUTANOATES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISEASE
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Page/Page column 9, (2012/11/13)
4-[(Haloalkyl)(dimethyl)ammonio]butanoates of formula (I) wherein Hal is Cl or F, n=1 or 2, method for preparing thereof and use thereof for treating cardiovascular disease.
