5429-29-8

Basic information

• Product Name: diethyl [2-(dimethylamino)ethyl]propanedioate
• CAS NO: 5429-29-8
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231.2887
• Mol File: 5429-29-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 286.5°C at 760 mmHg
• Flash Point: 127°C
• Density: 1.029g/cm³
• Vapor Pressure: 0.00264mmHg at 25°C
• Refractive Index: 1.448
• CAS DataBase Reference: diethyl [2-(dimethylamino)ethyl]propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl [2-(dimethylamino)ethyl]propanedioate(5429-29-8)
• EPA Substance Registry System: diethyl [2-(dimethylamino)ethyl]propanedioate(5429-29-8)

Safety Data

• Hazardous Substances Data: 5429-29-8(Hazardous Substances Data)

Upstream product

• 107-99-3 2-(dimethylamino)ethyl chloride 
• 105-53-3 diethyl malonate 
• 18721-64-7 diethyl 2-(2-bromoethyl)-malonate 
• 124-40-3 dimethyl amine 
• 141-82-2 malonic acid 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 141-52-6 sodium ethanolate 

Downstream Products

• 91285-23-3 7-(2-N,N-dimethylaminoethyl)-1,3-dimethyl-9-benzyl-6-hydroxy-9H-8-oxopyrimido[2,1-f]purine-2,4-dione 
• 1417800-00-0 [2-(2-diethylaminoethyl)-malonato][cis-(1,2-trans-cyclohexamethylenediamine)]platinum (II) tosilate 
• 5471-47-6 γ-Dimethylaminobutyrohydrazid 
• 118036-00-3 3-Dimethylaminopropylidenebismethylenebis(diphenylphosphine) 
• 117999-39-0 {4-Diphenylphosphanyl-3-[(diphenylphosphanyl)-methyl]-butyl}-dimethyl-amine; hydrochloride 
• 162051-22-1 α-(dimethylaminoethyl)-γ,γ-diphenyl-γ-butyrolactone 
• 22041-23-2 ethyl N,N-dimethyl-4-aminobutanoate 
• 28051-29-8 4-(2-dimethylamino-ethyl)-1,2-diphenyl-pyrazolidine-3,5-dione 

Relevant articles and documents

PLATINUM COMPOUNDS FOR TREATING CELL PROLIFERATIVE DISEASES, PREPARATION METHOD AND USE THEREOF

Disclosed are a class of platinum compounds with a leaving group of malonic acid derivatives containing amino and alkylamino, their pharmaceutically acceptable salts, their preparation methods and pharmaceutical composites comprising them. Disclosed also are for the uses of the compounds in the treatment of cell proliferative diseases, particularly for the treatment of cancers. The present platinum compounds have high water solubility and low toxicity.

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

Special (lipid) delivery: The role of the ionizable lipid pKa in the in?vivo delivery of siRNA by lipid nanoparticles has been studied with a large number of head group modifications to the lipids. A tight correlation between the lipid pKa?value and silencing of the mouse FVII gene (FVII ED50) was found, with an optimal pKa range of 6.2-6.5 (see graph). The most potent cationic lipid from this study has ED50 levels around 0.005?mg?kg?1 in mice and less than 0.03?mg?kg?1 in non-human primates.

Process for the preparation of vinylcyclopropane derivatives

This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yield. For the process an alkylating agent and activated methylene compound are reacted in the presence of a cyclic polyether compound and alkali metal compound. Water can also be present and/or the reaction may be carried out in an inert organic diluent.