5429-29-8

Upstream product

• 105-53-3 diethyl malonate 
• 18721-64-7 diethyl 2-(2-bromoethyl)-malonate 
• 124-40-3 dimethyl amine 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 141-82-2 malonic acid 
• 141-52-6 sodium ethanolate 

Downstream Products

• 22041-23-2 ethyl N,N-dimethyl-4-aminobutanoate 
• 91285-23-3 7-(2-N,N-dimethylaminoethyl)-1,3-dimethyl-9-benzyl-6-hydroxy-9H-8-oxopyrimido[2,1-f]purine-2,4-dione 
• 5471-47-6 γ-Dimethylaminobutyrohydrazid 
• 1417800-00-0 [2-(2-diethylaminoethyl)-malonato][cis-(1,2-trans-cyclohexamethylenediamine)]platinum (II) tosilate 
• 118036-00-3 3-Dimethylaminopropylidenebismethylenebis(diphenylphosphine) 
• 117999-39-0 {4-Diphenylphosphanyl-3-[(diphenylphosphanyl)-methyl]-butyl}-dimethyl-amine; hydrochloride 
• 162051-22-1 α-(dimethylaminoethyl)-γ,γ-diphenyl-γ-butyrolactone 
• 28051-29-8 4-(2-dimethylamino-ethyl)-1,2-diphenyl-pyrazolidine-3,5-dione 

Relevant academic research and scientific papers

PLATINUM COMPOUNDS FOR TREATING CELL PROLIFERATIVE DISEASES, PREPARATION METHOD AND USE THEREOF

Disclosed are a class of platinum compounds with a leaving group of malonic acid derivatives containing amino and alkylamino, their pharmaceutically acceptable salts, their preparation methods and pharmaceutical composites comprising them. Disclosed also are for the uses of the compounds in the treatment of cell proliferative diseases, particularly for the treatment of cancers. The present platinum compounds have high water solubility and low toxicity.

PLATINUM COMPOUNDS FOR TREATING CELL PROLIFERATIVE DISEASE, PREPARATION METHODS AND USES THEREOF

Disclosed are a class of platinum compounds with a leaving group of malonic acid derivatives containing amino and alkylamino, their pharmaceutically acceptable salts, their preparation methods and pharmaceutical composites comprising them. Disclosed also are for the uses of the compounds in the treatment of cell proliferative diseases, particularly for the treatment of cancers. The present platinum compounds have high water solubility and low toxicity.

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

Special (lipid) delivery: The role of the ionizable lipid pKa in the in?vivo delivery of siRNA by lipid nanoparticles has been studied with a large number of head group modifications to the lipids. A tight correlation between the lipid pKa?value and silencing of the mouse FVII gene (FVII ED50) was found, with an optimal pKa range of 6.2-6.5 (see graph). The most potent cationic lipid from this study has ED50 levels around 0.005?mg?kg?1 in mice and less than 0.03?mg?kg?1 in non-human primates.

Efficient 1,4-Asymetric Induction Utilizing Electrostatic Interaction between Ligand and Substrate in the Asymmetric Hydrogenation of Didehydrodipeptides

Electrostatic interaction between the amino group of the achiral 3-dimethylaminopropylidenebismethylenebis(diphenylphosphine) (1) and the carboxy group of the substrate enable an effective 1,4-asymmetric induction in the RhI-catalysed hydrogenation of didehydrodipeptides, to give (S,S)-or (R,R)-products selectively.The selectivity reached up to 94percent diastereoisomeric excess with acetyl didehydrodipeptides and 92percent with benzyloxycarbonyl substrates.

Process for the preparation of vinylcyclopropane derivatives

This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yield. For the process an alkylating agent and activated methylene compound are reacted in the presence of a cyclic polyether compound and alkali metal compound. Water can also be present and/or the reaction may be carried out in an inert organic diluent.

Process for the preparation of vinylcyclopropane derivatives

This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yield. For the process an alkylating agent and activated methylene compound are reacted in the presence of an alkylene oxide derivative and alkali metal compound. Water can also be present and/or the reaction may be carried out in an inert organic diluent.

Process for the preparation of vinylcyclopropane derivatives

This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yields. The process involves reacting an alkylating agent and an activated methylene compound in the presence of an onium compound, an alkali metal compound and water, which while only necessary in trace amounts can be present in substantial quantities.