220429-91-4

Upstream product

• 220429-90-3 C₃₃H₃₄Br₂O₆ 
• 85604-06-4 5-(benzyloxy)-2-bromobenzaldehyde 
• 591-31-1 3-methoxy-benzaldehyde 
• 220429-89-0 C₄₃H₃₄Br₂O₄ 
• 220429-88-9 (E)-1-[[4-(2-benzyloxy-5-dimethylphosphonomethyl)phenoxy]phenyl]-2-[2-bromo-5-methoxyphenyl]ethene 
• 220429-87-8 (E)-1-[4-(2-benzyloxy-5-methoxycarbonylphenoxy)phenyl]-2-[2-bromo-5-methoxyphenyl]ethene 
• 220429-85-6 methyl 3-(4-formylphenoxy)-4-benzyloxybenzoate 
• 220429-84-5 dimethyl [(2-bromo-5-methoxyphenyl)methyl]phosphonate 
• 1122-91-4 4-bromo-benzaldehyde 
• 150192-39-5 2-Bromo-5-methoxybenzyl alcohol 
• 87687-75-0 methyl 4-(benzyloxy)-3-hydroxybenzoate 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 19614-12-1 2-bromo-5-methoxybenzyl bromide 

Relevant academic research and scientific papers

Total synthesis of plagiochin D, a macrocyclic bis(bibenzyl) from liverworts by intramolecular Still-Kelly reaction

Plagiochin D (4), a unique macrocyclic bis(bibenzyl) having both a biphenyl ether and a biaryl units isolated from the liverwort Plagiochila acanthophylla, was synthesized. The key 16-membered ring closure of a dibromoperrottetin. A derivative 13 was realized by Pd(0) catalyzed intramolecular Still-Kelly reaction.

Total syntheses of plagiochins A and D, macrocyclic bis(bibenzyls), by Pd(0) catalyzed intramolecular Stille-Kelly reaction

Total syntheses of plagiochins A (1) and D (4), the former of which exhibits a significant neurotrophic activity, have been accomplished. The key 16-membered ring closure in 4 has been achieved directly from the dibromoperrottetin derivative (7) by Pd(0)