Total synthesis of plagiochin D, a macrocyclic bis(bibenzyl) from liverworts by intramolecular Still-Kelly reaction

Article abstract of DOI:10.1016/S0040-4039(98)80031-2

Plagiochin D (4), a unique macrocyclic bis(bibenzyl) having both a biphenyl ether and a biaryl units isolated from the liverwort Plagiochila acanthophylla, was synthesized. The key 16-membered ring closure of a dibromoperrottetin. A derivative 13 was realized by Pd(0) catalyzed intramolecular Still-Kelly reaction.