220441-82-7

Upstream product

• 3262-89-3 triphenylboroxine 
• 451503-18-7 (R)-N-((S)-(4-bromophenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide 
• 336105-24-9 (R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide 
• 100-58-3 phenylmagnesium bromide 
• 1122-91-4 4-bromo-benzaldehyde 
• 1309582-75-9 N,N'-sulfonyl bis-[(4-bromophenyl)(phenyl)methanamine] 
• 591-51-5 phenyllithium 
• 36176-92-8 N-(4-bromophenyl)methylidene-4-nitrobenzenesulfonamide 
• 840529-67-1 (S)-N-[(4-bromophenyl)phenylmethyl]-4-nitrobenzenesulfonamide 

Downstream Products

• 292066-65-0 (S)-(-)-α-(4-biphenylyl)benzylamine 
• 1380114-30-6 (S)-N-benzylidene-1-(4-bromophenyl)benzylamine 
• 292066-68-3 (S)-(-)-α-(4-biphenylyl)-N-(2,2-dimethoxyethyl)benzylamine 
• 292066-70-7 (S)-(+)-N-[α-(4-biphenylyl)benzyl]-N-(2,2-dimethoxyethyl)formamide 
• 91487-86-4 (S)-(+)-1-[α-(4-biphenylyl)benzyl]-1H-imidazole 

Relevant academic research and scientific papers

Compounds for Treating Cannabinoid Toxicity and Acute Cannabinoid Overdose

The present invention relates to novel compounds that can act as antidotes for treating “Acute Cannabinoid Overdose” produced by classical cannabinoids such as Δ9-tetrahydrocannabinol (THC) and several synthetic psychoactive cannabinoids (SPCs). The cannabis constituent THC exerts its psychotropic effects via CB1 receptor activation and SPCs mimic the effects of THC with higher potency and severe neurotoxicity. Compounds disclosed in this invention, their enantiomers, diastereomers, geometric isomers, racemates, tautomers, rotamers, atropisomers, metabolites, N-oxides, salts, solvates, hydrates, isotopic variations and their polymorphic forms can be therapeutically useful in an emergency setting for counteracting the intoxicating effects of acute THC ingestion and SPC overdose. Also, aspects of the invention are concerned with pyrazoles, imidazoles, triazoles, thiazoles, oxazoles, dihydropyrazoles, pyrrolidinones, azetidines, oxyazetidines and azaspiro[3.3]heptanes with unique pharmacokinetic and pharmacodynamic properties for treating “Acute Cannabinoid Overdose”.

Bis-sulfamyl imines: Potent substrates for asymmetric additions of arylboroxines under rhodium catalysis

Bis-sulfamyl imines are shown to be potentially ideal substrates for rhodium-catalysed asymmetric additions of arylboron nucleophiles as they show: (i) near perfect enantioselectivities (11 examples, 98-99+% ee), (ii) good to excellent diastereoselectivities (10-32:1 rac:meso), and (iii) high functional group tolerance in removal of the low molecular weight protecting group via mild heating in aqueous pyridine.

C2-symmetric bicyclo[3.3.1]nonadiene as a chiral ligand for rhodium-catalyzed asymmetric arylation of N-(4-nitrobenzenesulfonyl)arylimines

(Chemical Equation Presented) Asymmetric synthesis of diarylmethylamines with high enantioselectivity (95-99percent ee) was realized by use of a new C 2-symmetric diene ligand, (1R,5R)-2,6-diphenylbicyclo[3.3.1]nona-2,6- diene (Ph-bnd*), for th

Asymmetric synthesis of diarylmethylamines: Preparation of selective opioid delta receptor ligands

Two different methods were used for the construction of optically active diarylmethylamines. Diastereoselective alkylation on an aldimine/oxazolidine 2a/2b derived from (R)/(S)-phenylglycinol or enantioselective reduction of 4- [η6-chromium tri