336105-24-9

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Downstream Products

• 865355-02-8 2-Methyl-propane-2-sulfinic acid [(1S,2R)-1-(4-bromo-phenyl)-2-hydroxy-3-methyl-butyl]-amide 
• 451503-19-8 (R)-N-((R)-(4-bromophenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide 
• 451503-18-7 (R)-N-((S)-(4-bromophenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide 
• 220441-82-7 (S)-(4-bromophenyl)(phenyl)methanamine 
• 1508278-89-4 C₂₄H₄₂BrNO₄SSi 
• 1508278-87-2 C₂₉H₅₀BrNO₄SSi 
• 1508278-86-1 C₃₁H₄₉BrN₂O₄SSi 
• 1508278-85-0 C₂₉H₄₃BrFNO₄SSi 
• 1508278-84-9 C₃₃H₄₆BrNO₄SSi 
• 1508278-74-7 C₂₉H₄₄BrNO₄SSi 
• 1428526-95-7 (R)-N-((R)-(4-bromophenyl)(4-fluorophenyl)methyl)-2-methylpropane-2-sulfinamide 
• 1428527-51-8 4-((R)-(2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxamido)(4-fluorophenyl)methyl)phenyl(methyl)phosphinic acid 
• 1428527-50-7 ethyl 4-((R)-(2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxamido)(4-fluorophenyl)methyl)phenyl(methyl)phosphinate 
• 1428527-23-4 4-((R)-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl) methyl)phenyl(methyl)phosphinic acid 

Relevant academic research and scientific papers

Stereoselective Coupling of N-tert-Butanesulfinyl Aldimines and β-Keto Acids: Access to β-Amino Ketones

The reaction of chiral N-tert-butanesulfinyl aldimines with β-keto acids under basic conditions at room temperature proceeds with high levels of diastereocontrol, leading to β-amino ketones in high yields. Based on DFT calculations, an eight-membered cyclic transition state involving coordination of the lithium atom to the oxygens of carboxylate and sulfinyl units was proposed, being in agreement with the observed experimental diastereomeric ratios. The synthesis of the piperidine alkaloid (-)-pelletierine was successfully undertaken in order to demonstrate the utility of this methodology.

SUBSTITUTED PYRIMIDINES

Disclosed are substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

Asymmetric synthesis of diarylmethylamines by diastereoselective addition of organometallic reagents to chiral N-tert-butanesulfinimines: Switchover of diastereofacial selectivity

Diastereoselective addition of organometallic reagents to chiral N-tert-butanesulfinimines gave alkylated adducts in high yields and diastereoselectivities. Cleavage of the chiral auxiliary under mildly acidic conditions gave diarylmethylamines in high yi