220475-13-8

Basic information

• Product Name: (2R,4R)-N-benzyl-4-benzyloxyproline methyl ester
• Synonyms: (2R,4R)-N-benzyl-4-benzyloxyproline methyl ester
• CAS NO: 220475-13-8
• Molecular Weight: 325.408
• Mol File: 220475-13-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4R)-N-benzyl-4-benzyloxyproline methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-N-benzyl-4-benzyloxyproline methyl ester(220475-13-8)
• EPA Substance Registry System: (2R,4R)-N-benzyl-4-benzyloxyproline methyl ester(220475-13-8)

Safety Data

• Hazardous Substances Data: 220475-13-8(Hazardous Substances Data)

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 220475-15-0 (2R,4R)-N-benzyl-4-benzyloxy-2-formylpyrrolidine 
• 220475-17-2 (2R,4R,1'S)-N-benzyl-4-benzyloxy-2-(1'-hydroxy-3'-butenyl)pyrrolidine 
• 220475-20-7 (2R,4R,1'S)-N-benzyl-4-benzyloxy-2-(1'-benzyloxy-3'-butenyl)pyrrolidine 
• 220475-23-0 (2R,4R,1'S)-N-benzyl-4-benzyloxy-2-(1'-benzyloxy-4'-hydroxybutyl)pyrrolidine 
• 220475-14-9 (2R,4R)-N-benzyl-2-hydroxymethyl-4-benzyloxypyrrolidine 

Relevant articles and documents

Synthesis and activity as a glycosidase inhibitor of 2,8-dihydroxyindolizidines

The synthesis and enzyme assay of 2,8-dihydroxyindolizidines (5) were described. Four diastereomers of these were prepared from trans-4-hydroxy-L-proline (6) which is commercially available amino acid. Among synthetic compounds 5a1 and 5b2 showed medium potent inhibition to α-amyloglycosidase, while 5a2 displayed medium activity to α-glucosidase.