220495-53-4Relevant academic research and scientific papers
AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS
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Page/Page column 21, (2009/02/11)
The present invention provides a compound of formula I: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS
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Page/Page column 30-31, (2008/06/13)
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor: (I) wherein the variables are described in the specification.
Bergman cycloaromatization of imidazole-fused enediynes: The remarkable effect of N-aryl substitution
Zhao, Zhengrong,Peng, Yunshan,Dalley, N. Kent,Cannon, John F.,Peterson, Matt A.
, p. 3621 - 3624 (2007/10/03)
A series of N-aryl substituted 'imidazole-fused' (Z) 3-ene-1,5-diynes was prepared and kinetic parameters for their Bergman cycloaromatization reactivities were determined. N-Arylation enhanced rates relative to N-alkyl derivatives by up to sevenfold (ANOVA p0.0001). The greatest enhancement was exhibited by the N-phenyl derivative (sevenfold at 145°C).
