220585-01-3

Upstream product

• 624736-74-9 ethyl (6R)-5-(1,3-benzodioxol-5-yl)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(4-methoxyphenyl)-5,6-dihydro-4H-1,2-oxazine-4-carboxylate 
• 624736-70-5 (6R)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine 
• 624736-67-0 6-ethoxy-3-(p-methoxyphenyl)-6H-1,2-oxazine 
• 71426-53-4 α-bromo-(p-methoxy)acetophenonoxime 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 624736-80-7 (2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 

Relevant academic research and scientific papers

Enantioselective synthesis of the pyrrolidine core of endothelin antagonist ABT-627 (Atrasentan) via 1,2-oxazines

Diastereoselective syntheses of the pyrrolidine core 6a of the endothelin antagonist ABT-627 (Atrasentan) either as a racemic mixture or as an enantiopure compound are presented. The crucial steps of these syntheses utilized the highly diastereoselective