2206-89-5Relevant academic research and scientific papers
Applications of pH sensor using a covalent bond indicator based on containing functional group copolymer
Kang, Eun-Hee,Ham, Jin-Kyoung,Shim, Jong-Min,Lee, Jin-Kook,Kim, Mi-Ra
, p. 285/[575]-290/[580] (2006)
The purpose of this study was to immobilize copolymer that is able to covalent bonding with pH indicator. The pH sensitive polymers were synthesized with copolymers that are consisted of acryloylamino acid and chloroalkyl acrylate with MMA to get the optical fiber matrix. Fluoresceinamine indicator, containing amino group was immobilized covalently on prepared copolymers. The prepared pH sensing copolymers were measured sensitivity by UV-Visible spectroscopy. The pH-dependent value of copolymers was examined in the pH range of 2.00 ~ 12.00 HCl/NaOH solution at room temperature. As the length side chain and MMA molar ratio of the copolymers increases, the intensity decreases. Compared with imine group of copolymer-dye derivatives, amide group derivatives have a bathochromic shift on the UV-Visible spectrum.
Intramolecular Photochemical Reactions of 4-(ω-Alkenyloxy)-6-methyl-2-pyrones Having an Alkoxycarbonyl Group at the Olefinic Carbon Chain
Shimo, Tetsuro,Tajima, Jun,Suishu, Takaaki,Somekawa, Kenichi
, p. 7150 - 7154 (1991)
Photochemical reactions of 4-(ω-alkenyloxy)-6-methyl-2-pyrones 4-8 were investigated.Photosensitized reactions of 2-pyrones 4-6 gave intramolecular cycloadducts 14-16 as oxatricyclic lactones, site-, regio- and stereospecifically, but 7 and 8 gave no products.On the other hand, direct irradiations of 4 and 5 afforded cyclobutenecarboxylic acids 19 and 20, respectively.The intramolecular cycloaddition mechanism was also explained from the excited state of 2-pyrone calculated by means of the MNDO-CI method.
Ti-Catalyzed Radical Alkylation of Secondary and Tertiary Alkyl Chlorides Using Michael Acceptors
Wu, Xiangyu,Hao, Wei,Ye, Ke-Yin,Jiang, Binyang,Pombar, Gisselle,Song, Zhidong,Lin, Song
supporting information, p. 14836 - 14843 (2018/11/10)
Alkyl chlorides are common functional groups in synthetic organic chemistry. However, the engagement of unactivated alkyl chlorides, especially tertiary alkyl chlorides, in transition-metal-catalyzed C-C bond formation remains challenging. Herein, we describe the development of a TiIII-catalyzed radical addition of 2° and 3° alkyl chlorides to electron-deficient alkenes. Mechanistic data are consistent with inner-sphere activation of the C-Cl bond featuring TiIII-mediated Cl atom abstraction. Evidence suggests that the active TiIII catalyst is generated from the TiIV precursor in a Lewis-acid-assisted electron transfer process.
Enhanced Antimetastatic Activity of the Ruthenium Anticancer Drug RAPTA-C Delivered in Fructose-Coated Micelles
Lu, Mingxia,Chen, Fan,Noy, Janina-Miriam,Lu, Hongxu,Stenzel, Martina H.
, (2017/10/16)
The ruthenium complex—dichlororuthenium (II) (p-cymene) (1,3,5-triaza-7-phosphaadamantane) (RAPTA-C)—has shown to be remarkably effective at suppressing the growth of solid tumor metastases. However, poor delivery efficacy and the lack of targeting ability of the common drug delivery system pose significant obstacles to maximize the therapeutic benefit of RAPTA-C. Inspired by the overexpression of GLUT5 transporter on the surface of breast cancer tissues but not the healthy mammary tissues, the use of d-fructose as the targeting moiety of the drug carrier can significantly improve the cellular uptake of nanoparticles, thus further enhancing the therapeutic efficiency of RAPTA-C. In this work, fructose-micelles and 2-hydroxyethyl acrylate (HEA)-micelles are prepared to investigate the difference in cellular uptake. It is found that glycopolymer leads to an increased uptake by breast cancer cells, while the HEA-micelles show less uptake. This behavior is also reflected by the slightly faster movement of fructose-coated micelles in MCF-7 tumor spheroid models using light sheet microscopy as analytical tool. The incorporation of RAPTA-C into micelles can enhance the inhibitory effect of the ruthenium drug demonstrated using invasion, chemotaxis, and haptotaxis assays. As a result, fructose-coated nanoparticles can be a promising drug delivery platform of RAPTA-C for the treatment of metastatic breast cancer. (Figure presented.).
Synthesis of acyloxyalkyl esters of thiocarbonic and dithiocarbamic acids
Mustafaev,Kulieva,Mustafaev,Kulibekova,Kakhramanova,Safarova,Novotorzhina
, p. 198 - 203 (2013/07/25)
Reactions of acyloxyalkyl chloride with alkaline salts of alkylxanthic, butyltrithiocarbonic, and diethyldithiocarbamic acids afforded a series of acyloxyalkyl esters of various nature and positions of the acyl groups in the molecule.
New selective syntheses of (Meth)acrylic monomers: Isocyanates, isocyanurates, carbamates and ureas derivatives
Dubosclard-Gottardi, Christine,Caubere, Paul,Fort, Yves
, p. 2561 - 2572 (2007/10/02)
The selective formulation of ω-isocyanatoalkyl (meth)acrylates may be conveniently obtained by simple condensation of potassium cyanate with ω-halogeno-alkyl (meth)acrylates under appropriated phase transfer catalytic conditions. Depending on the reaction media and the temperature, these isocyanate derivatives may be isolated, trimerized to the corresponding isocyanurates or trapped in situ as carbamates or ureas compounds.
The 'Baylis - Hillman reaction' mechanism and applications revisited
Fort, Yves,Berthe, Marie Christine,Caubere, Paul
, p. 6371 - 6384 (2007/10/02)
It is shown that reaction of aryl, benzyl, alkyl and functionalised alkyl acrylic esters with benzaldehyde, in the presence of 1,4-diazabicyclo[2.2.2] octane, strongly depends upon the electronic and steric effects of the ester part. This influence is also observed in condensation of furfuraldehyde. Moreover, for the first time, it is shown that the overall condensation is equilibrated.
