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220616-06-8

220616-06-8

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220616-06-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 220616-06-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,6,1 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 220616-06:
(8*2)+(7*2)+(6*0)+(5*6)+(4*1)+(3*6)+(2*0)+(1*6)=88
88 % 10 = 8
So 220616-06-8 is a valid CAS Registry Number.

220616-06-8Relevant articles and documents

Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770

Curtin, Michael L.,Florjancic, Alan S.,Heyman,Michaelides, Michael R.,Garland, Robert B.,Holms, James H.,Steinman, Douglas H.,Dellaria, Joseph F.,Gong, Jane,Wada, Carol K.,Guo, Yan,Elmore, Ildiko B.,Tapang, Paul,Albert, Daniel H.,Magoc, Terrance J.,Marcotte, Patrick A.,Bouska, Jennifer J.,Goodfellow, Carole L.,Bauch, Joy L.,Marsh, Kennan C.,Morgan, Douglas W.,Davidsen, Steven K.

, p. 1557 - 1560 (2007/10/03)

Modification of the biphenyl portion of MMP inhibitor 2a gave analogue 2i which is greater than 1000-fold selective against MMP-2 versus MMP-1. The stereospecific synthesis of both enantiomers of 2i was achieved beginning with (S)- or (R)-benzyl glycidyl ether. The (S)-enantiomer, 11 (ABT-770), is orally bioavailable and efficacious in an in vivo model of tumor growth. Elsevier Science Ltd. All rights reserved.

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