220693-38-9Relevant articles and documents
Zidampidine, an aryl phosphate derivative of AZT: In vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus
Uckun,Venkatachalam,Erbeck,Chen,Petkevich,Vassilev
, p. 3279 - 3288 (2005)
The pharmacokinetics, metabolism, and toxicity of Zidampidine, an aryl phosphate derivative of AZT, 3′-azidothymidine-5′-[p-bromophenyl methoxyalaninyl phosphate] were investigated in CD-1 mice. Following iv injection, Zidampidine was rapidly converted to
Aryl phosphate derivatives of d4T having anti-HIV activity
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Page column 15-16, (2008/06/13)
Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse transcriptase. In a preferred aspect of the present invention, the phosphorus of the aryl phosphate group is further substituted with an amino acid residue that may be esterified or substituted, such as a methoxy alaninyl group.
