213982-96-8

Basic information

• Product Name: WHI-07
• CAS NO: 213982-96-8
• Molecular Weight: 698.262
• Mol File: 213982-96-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: WHI-07(CAS DataBase Reference)
• NIST Chemistry Reference: WHI-07(213982-96-8)
• EPA Substance Registry System: WHI-07(213982-96-8)

Safety Data

• Hazardous Substances Data: 213982-96-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 213906-39-9 (S)-2-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(4-bromo-phenoxy)-phosphorylamino]-propionic acid methyl ester 
• 220693-38-9 3'-azidothymidine-5'-(p-bromophenyl)methoxyalaninyl phosphate 
• 217090-42-1 4-bromophenyl methoxy-alanyl phosphorochloridate 
• 19430-76-3 p-bromophenyl phosphorodichloridate 
• 106-41-2 4-bromo-phenol 

Relevant articles and documents

Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds: Studies using human acute lymphoblastic leukemia cells and the zebrafish model

The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate. ECV · Editio Cantor Verlag, Aulendorf (Germany).