Chemical Property of Potassium oxonate
Chemical Property:
- Appearance/Colour:off-white solid
- Melting Point:300 °C(lit.)
- PSA：118.74000
- LogP:-3.17830
- Storage Temp.:Refrigerator, Under Inert Atmosphere
- Solubility.:Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated)
- Water Solubility.:Soluble in hot water.
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:1
- Exact Mass:194.96823704
- Heavy Atom Count:12
- Complexity:274
- Purity/Quality:
-
99% *data from raw suppliers
NOX4 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1(=NC(=O)NC(=O)N1)C(=O)[O-].[K+]
- Recent NIPH Clinical Trials:A phase II study of S-1 plus resminostat for biliary tract cancer
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Description
Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; ), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats. Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.
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Uses
Antitumor effect potentiator and antitumor agent Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats.It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism. Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
