220751-29-1Relevant academic research and scientific papers
Base-catalyzed amination of olefins: An example of an environmentally friendly synthesis of amines
Beller, Matthias,Breindl
, p. 21 - 26 (2001)
The base-catalyzed amination of aromatic olefins is described as an environmentally friendly synthesis of various β-arylethylamines. Primary and secondary aliphatic amines as well as aromatic amines react with styrene derivatives to give the corresponding β-arylethylamines in high yield up to 99%. While aliphatic amines react with styrenes in the presence of n-BuLi as the pre-catalyst, anilines can be olefinated using KOtBu as the catalyst.
Facile Synthesis and Isolation of Secondary Amines via a Sequential Titanium(IV)-Catalyzed Hydroamination and Palladium-Catalyzed Hydrogenation
Lui, Erica K. J.,Schafer, Laurel L.
supporting information, p. 713 - 718 (2016/03/09)
An atom economical and catalytic route for the synthesis of aryl- and alkyl-substituted secondary amines has been developed. Using a bis(amidate)bis(amido)titanium(IV) precatalyst, the hydroamination of terminal alkynes with a range of amines results in the selective formation of the anti-Markovnikov product. The crude enamine/imine mixtures are effectively hydrogenated using palladium on carbon (Pd/C) and H2 to afford the corresponding secondary amine in excellent yields. Simple work-up procedures allow for the isolation of pure compounds while avoiding purification via column chromatography.
PROLYL HYDROXYLASE ANTAGONISTS
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Page/Page column 96, (2010/11/26)
This invention relates to certain 2-[(quinolin-3-yl)carbonyl]aminoacetic acid derivatives of formula (I), where the various groups are defined herein, and which are useful in treating anemia.
Catalytic synthesis of N-alkylated anilines from olefins and anilines
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, (2008/06/13)
Process for the preparation of an N-arylethylaniline of the formula (I) Ar—N(R1)2-n(CHR2CHR3Ar′)n??(I) by reacting an aromatic olefin of the formula (II) Ar′CR3=CHR2??(II) with a
Amination of aromatic olefins with anilines: A new domino synthesis of quinolines
Beller, Matthias,Thiel, Oliver R.,Trauthwein, Harald,Hartung, Christian G.
, p. 2513 - 2522 (2007/10/03)
A new catalytic amination of aromatic olefins with anilines is presented. In a domino reaction, substituted quinoline derivatives are obtained in the presence of cationic rhodium complexes, such as [Rh(cod)2]BF4, and PPh3. Ethylbenzene is formed as a by-product in this new oxidative reaction. The first transition metal catalyzed anti-Markovnikov hydroamination of styrene with anilines occurs as a side reaction. Mechanistic investigations strongly support the regioselective oxidative amination of styrene as the key reaction step.
