220778-86-9

Upstream product

• 1571-08-0 methyl 4-formylbenzoate 
• 1663-39-4 tert-Butyl acrylate 
• 75-36-5 acetyl chloride 
• 220779-45-3 tert-butyl 3-hydroxy-2-methylene-3-(4-(methoxycarbonyl)phenyl)propanoate 

Downstream Products

• 169320-84-7 methyl 4-(2-tert-butoxycarbonylpropenyl)benzoate 
• 187682-17-3 -3-(4-(methoxycarbonyl)phenyl)-2-methylprop-2-enoic acid 

Relevant academic research and scientific papers

ARYLAMINOMETHYL PROPENYL BENZHYDROXYAMID DERIVATIVES WITH INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND METHOD FOR THE PREPARATION THEREOF

This invention discloses a novel arylaminomethyl propenyl benzhydroxyamide derivative of formula (I) useful for preventing or treating various diseases induced by histone deacetylase, a method for preparing same and a pharmaceutical composition comprising

A facile one-pot conversion of acetates of the Baylis-Hillman adducts to [E]-α-methylcinnamic acids

A simple and convenient stereoselective synthesis of [E]-α- methylcinnamic acids via the nucleophilic addition of hydride ion from sodium borohydride to methyl 3-acetoxy-3-aryl-2-methylenepropanoates followed by hydrolysis and crystallization is described