220862-19-1

Upstream product

• 220862-18-0 tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate 
• 1118-02-1 trimethylsilyl isocyanate 
• 38857-88-4 bis(2,2,2-trichloroethyl)azodicarboxylate 

Downstream Products

• 257939-87-0 [[2-Ethyl-1-(phenylmethyl)-3-ureido-1H-indol-4-yl]oxy]acetic acid 

Relevant academic research and scientific papers

Method for treating sepsis

A novel method of treating and/or preventing sepsis.

Method for the treatment of renal dysfunction with spla2 inhibitors

A method is disclosed for the treatment of of the symptoms associated with renal dysfunction by administering to an animal in need thereof a therapeutically effective amount of a sPLA2 inhibitor, such as a 1H-indole-3-glyoxylamide.

METHOD FOR TRATMENT OF NON-RHEUMATOID ARTHRITIS

A method is disclosed for the treatment of non-rheumatoid arthritis by administering to a mammal in need thereof a therapeutically effective amount of an sPLA 2 inhibitor.

Method for the treatment of cystic fibrosis

A method is disclosed for the treatment of cystic fibrosis by administering to a human in need thereof a therapeutically effective amount of an sPLA2inhibitor, such as a 1H-indole-3-glyoxylamide.

Indole sPLA2 inhibitors

A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.

Treatment for alzheimer's disease

This invention is a method of treating a mammal, including a human, susceptible to having Alzheimer's disease, to prevent or delay the onset of Alzheimer's disease; said method comprising administering to said mammal a prophylactically effective amount of