220862-18-0

Usage

Uses

Used in Chemical Synthesis:
Tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate is utilized as a reagent in chemical synthesis for its ability to participate in various organic reactions, contributing to the formation of new compounds with potential applications in different fields.
Used in Pharmaceutical Development:
In the pharmaceutical industry, tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate is used as a precursor or intermediate in the synthesis of drug candidates. Its unique structure may offer specific biological activities or serve as a building block for the development of new medications.
Used in Agrochemical Research:
Similarly, in agrochemicals, tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate is employed for its potential to contribute to the creation of new pesticides, herbicides, or other agrochemical products, thanks to its reactivity and structural features.
The specific uses and properties of tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate are highly context-dependent, and its effects on biological systems and chemical reactions can vary widely based on the particular application and environment in which it is used.

InChI:InChI=1/C23H27NO3/c1-5-18-14-19-20(24(18)15-17-10-7-6-8-11-17)12-9-13-21(19)26-16-22(25)27-23(2,3)4/h6-14H,5,15-16H2,1-4H3

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 172733-06-1 1-benzyl-2-ethyl-1H-indol-4-ol 
• 863870-77-3 3-chloro-2-iodophenyl N,N-dimethyl O-carbamate 
• 945470-36-0 2-but-1-ynyl-1-chloro-3-methoxybenzene 
• 20289-26-3 4-benzyloxy-1H-indole 
• 79315-62-1 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole 
• 2380-94-1 1H-indol-4-ol 
• 889675-05-2 1-(4-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone 
• 889675-07-4 1-benzyl-4-(benzyloxy)-2-ethyl-1H-indole 
• 889675-06-3 1-(4-(benzyloxy)-1H-indol-2-yl)ethanol 
• 39843-70-4 4-(benzyloxy)-2-ethyl-1H-indole 
• 164082-80-8 1-benzyl-2-ethyl-4-methoxy-1H-indole 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 791642-67-6 1-chloro-2-iodo-3-methoxybenzene 

Downstream Products

• 889675-08-5 tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate 
• 220862-19-1 [[2-ethyl-1-(phenylmethyl)-3-ureido-1H-indol-4-yl]oxy]acetic acid tert-butyl ester 
• 172732-68-2 ((3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetic acid 

Relevant academic research and scientific papers

Regioselective synthesis of 4- and 7-alkoxyindoles from 2,3-dihalophenols: Application to the preparation of indole inhibitors of phospholipase A 2

(Chemical Equation Presented) An efficient and regioselective synthesis of 4- and 7-alkoxyindoles has been developed from commercially available starting materials such as 3-halophenols and 3-chloroanisole. Directed ortho-metalation followed by two pallad

The first potent inhibitor of mammalian group X secreted phospholipase A2: Elucidation of sites for enhanced binding

Using the X-ray structure of human group X secreted phospholipase A 2 (hGX), we carried out structure-based design of indole-based inhibitors and prepared the compounds using a new synthetic route. The most potent compound inhibited hGX and the mouse orthologue with an IC50 of 75 nM. This compound is the most potent hGX inhibitor reported to date and was also found to inhibit a subset of the other mouse and human SPLA 2S.

Method for treating sepsis

A novel method of treating and/or preventing sepsis.

Method for the treatment of renal dysfunction with spla2 inhibitors

A method is disclosed for the treatment of of the symptoms associated with renal dysfunction by administering to an animal in need thereof a therapeutically effective amount of a sPLA2 inhibitor, such as a 1H-indole-3-glyoxylamide.

METHOD FOR TRATMENT OF NON-RHEUMATOID ARTHRITIS

A method is disclosed for the treatment of non-rheumatoid arthritis by administering to a mammal in need thereof a therapeutically effective amount of an sPLA 2 inhibitor.

Method for the treatment of cystic fibrosis

A method is disclosed for the treatment of cystic fibrosis by administering to a human in need thereof a therapeutically effective amount of an sPLA2inhibitor, such as a 1H-indole-3-glyoxylamide.

Indole sPLA2 inhibitors

A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.

Treatment for alzheimer's disease

This invention is a method of treating a mammal, including a human, susceptible to having Alzheimer's disease, to prevent or delay the onset of Alzheimer's disease; said method comprising administering to said mammal a prophylactically effective amount of