2209-59-8Relevant academic research and scientific papers
Two complexes from one reaction of nickel(II) ion with a new Schiff base ligand
Wang, Hong Yan,Zhao, Pu Su,Song, Jie,Li, Rong Qing
, p. 379 - 385 (2011)
A new Schiff base ligand of 1-(2, 6-dichlorobenzylidene)-4- phenylthiosemicarbazide(C14H11Cl2N 3S) has been synthesized, which crystallizes in monoclinic, space group C2/c with a = 18.551(7) A, b = 6.963(3) A, c
Crystal structure and spectroscopic characterization of bis(N-phenylthiourea)
Akinchan, Narayan T.,Drozdzewski, Piotr M.,Battaglia, Luigi P.
, p. 91 - 97 (2002)
Bis(N-phenylthiourea) (BPTU) has been synthesized and characterized by means of X-ray, IR, Raman, UV-Vis, 1H NMR, and FAB mass spectra. The BPTU crystal belongs to the monoclinic C2/c space group with the cell constants a = 26.992(8) A, b = 6.3
Preparation and antitubercular activities of palindromic hydrazinecarbothioamides and carbonothioic dihydrazides
Hearn, Michael Joseps,Towers, Gwendolyn,Cynamon, Michael Henry
, p. 1202 - 1210 (2019/11/22)
Background: With approximately one-third of the world’s population infected, tuberculosis continues to be a global public health crisis. The rise of strains that are unusually virulent or highly resistant to current drugs is a cause of special concern, pr
Synthesis and characterization of N-glucosylated dithiadiazepine derivatives through carbon-sulfur bond formation
Chavan, Snehal A.,Ulhe, Avinash G.,Berad, Baliram N.
, p. 269 - 272 (2015/10/28)
New 4,7-bis(arylamino)-2-tetra-O-acetyl-β-d-glucopyranosylimino-1,3,5,6-dithiadiazepines were synthesized via reaction of N-tetra-O-acetyl-β-d-glucopyranosyl isocyanodichloride with 1,6-diaryl-2,5-dithio-bis-ureas without using any catalyst. Thus, the syn
Dithiocarbamates as an efficient intermediate for the synthesis of symmetrical substituted 2,5-diamino-1,3,4-thiadiazoles in water
Halimehjani, Azim Ziyaei,Ashouri, Akram,Marjani, Katayoun
, p. 939 - 942 (2012/10/29)
Synthesis of symmetrical substituted 2,5-diamino-1,3,4-thiadiazoles is described. Reaction of easily prepared dithiocarbamates with hydrazine gives the corresponding thiadiazoles in moderate to good yields. This method is new, efficient, and simple especi
Novel and efficient cyclization procedure for the synthesis of 2,5-disubstituted-1,3,4-thiadiazoles without using any ring-closing reagents
Lin, Qi,Zhang, You-Ming,Li, Man-Lin,Wei, Tai-Bao
experimental part, p. 3251 - 3260 (2012/09/10)
A novel method for the synthesis of 2,5-disubstituted-1,3,4-thiadiazoles via direct ring closure of 1,6-disubstituted-2,5-dithioureas in dimethylformanide without using any ring-closing reagents has been accidentally discovered. Repeated and extended experiments confirmed that this is a very simple and efficient way to synthesize these kinds of fine chemicals. A series of novel 2,5-disubstituted-1,3,4-thiadiazoles have been synthesized via this method in good yields.
Desulfurization strategy in the construction of azoles possessing additional nitrogen, oxygen or sulfur using a copper(I) catalyst
Guin, Srimanta,Rout, Saroj Kumar,Gogoi, Anupal,Nandi, Shyamapada,Ghara, Krishna Kanta,Patel, Bhisma K.
, p. 2757 - 2770 (2013/01/15)
A tandem and convergent approach to various N-, O-, or S-containing azoles has been developed by exploiting the thiophilic property of copper( I) iodide used in a catalytic quantity. The present protocol gives access to amino-substituted tetrazoles, triazoles, oxadiazoles and thiadiazoles via oxidative desulfurization of their respective precursors followed by inter- or intramolecular attack of suitable nucleophiles. For aminotetrazoles and triazoles an excellent regioselectivity has been achieved through proper tuning of the pKa values of the parent amines attached to unsymmetrical thioureas. The method represents an autocatalytic process in which copper( I) iodide gets converted to copper(II) sulfide which in turn transforms to active copper(II) oxide that effectively carries forward the catalytic cycle. The fate of the copper catalyst has also been studied using scanning electron microscopic (SEM) and energy-dispersive X-ray spectroscopic (EDS) analyses which give an insight into the mechanism for this catalytic process.
Tandem regioselective synthesis of tetrazoles and related heterocycles using iodine
Yella, Ramesh,Khatun, Nilufa,Rout, Saroj Kumar,Patel, Bhisma K.
supporting information; experimental part, p. 3235 - 3245 (2011/06/20)
A one-pot, tandem process has been developed for the synthesis of a library of tetrazoles from aryl isothiocyanates. Condensation of aryl isothiocyanates with ammonia, and aryl amines (R-NH2) provided mono, 1,3-disubstituted symmetrical and unsymmetrical thioureas, which on desulfurization with molecular iodine (I2) led to formation of the corresponding heterocumulene (cyanamides or carbodiimides). The in situ generated heterocumulene on subsequent treatment with sodium azide at room temperature gave corresponding tetrazoles. The product regioselectivity for unsymmetrical 1,3-disubstituted thioureas was found to be correlated with the basicities (pKa's) of the parent amines attached to the thiourea. Aryl-sec-alkyl unsymmetrical thioureas gave thioamido guanidino products rather than the 5-aminotetrazoles produced by HgCl2 mediation of the reaction. Bis-thioureas derived from aryl isothiocyanates and hydrazine gave thiadiazoles exclusively.
Thermolysis of symmetrical dithiobiurea and thioureidoethylthiourea derivatives
Hassan, Alaa A.,Mourad, Aboul-Fetouh E.,El-Shaieb, Kamal M.,Abou-Zied, Ashraf H.,Doepp, Dietrich
, p. 535 - 541 (2007/10/03)
Microwave and thermal heterocyclization of N,N′-disubstituted hydrazinecarbothioamide 1a,b and substituted thioureidoethylthioureas 2a-c as well as 1-phenyl-3[2-(3-phenylthio-ureido)phenyl]-thiourea 6 are reported.
Migration of an acyl group in the pyrazole system: Synthesis of 1-acyl-3-hydroxy-1H-pyrazoles and related derivatives. A new preparation of N,N′-diacylhydrazines
Kepe, Vladimir,Pozgan, Franc,Golobic, Amalija,Polanc, Slovenko,Kocevar, Marijan
, p. 2813 - 2816 (2007/10/03)
A new general method for the synthesis of 1-acyl-3-hydroxy-1H-pyrazoles 5a-f and related derivatives 5g-i starting from 4-ethoxymethylene-2-phenyloxazol-5(4H)-one (1) and hydrazides, 4-phenylsemicarbazide, 4-phenylthiosemicarbazide and benzyl carbazate in boiling dioxane is described. The method includes a migration of an acyl or related unit. The X-ray study and NMR spectroscopic examination confirmed the structure of the products. A one-pot synthesis of N,N′-diacylhydrazines from hydrazides by the assistance of oxazolone 1 is also presented.
