1152-54-1Relevant academic research and scientific papers
Influence of pH values on the self-assembly in three trinuclear nickel complexes with bridging ligand N-salicylyl 4-phenyl-thiosemicarbazide
Du, Kang-Kai,Liu, Shi-Xiong
, p. 138 - 144 (2008)
Three trinuclear nickel complexes containing N-salicylyl 4-phenyl-thiosemicarbazide(abbreviated as spt3-) have been synthesized. They are complex [Ni3(spt)2(dpt)2]·2C3H7NO (1) with 2,5-diphenylamiyl 1,3,4 thiodiazone ligand(dpt) and the other two complexes without dpt ligand ([Ni3(spt)2(H2O)4]·2C3H7NO (2) and [Ni3(spt)2(C5H5N)2(H2O)2]·2C3H7NO (3)). Central Ni atom and two terminal Ni atoms in the three complexes are combined by two bridging deprotonated spt3- ligands, forming a strictly linear trinuclear nickel structure unit with a Ni{single bond}N{single bond}N{single bond}Ni{single bond}N{single bond}N{single bond}Ni core. There is an extended 1D structure in 2 and 3 formed by intermolecular hydrogen bonds O{single bond}H...O. The influence of pH of the reaction medium upon the composition of the final products is discussed.
Acetylacetonate bis(thiosemicarbazone) complexes of copper and nickel: Towards new copper radiopharmaceuticals
Cowley, Andrew R.,Dilworth, Jonathan R.,Donnelly, Paul S.,Gee, Antony D.,Heslop, Julia M.
, p. 2404 - 2412 (2004)
A series of copper(II) and nickel(II) 1,3-bis(thiosemicarbazonato) complexes have been synthesised by the reaction of the metal acetates with pyrazoline proligands. In each case the complexes have an overall neutral charge with a dianionic ligand. The cop
Preparation of 2,5-diamino-1,3,4-thiadiazole derivatives using MgO nanoparticles as heterogeneous basic catalysts
Ashouri, Akram,Samadi, Saadi
, p. 1297 - 1304 (2019)
Abstract: The synthesis of 2,5-diamino-1,3,4-thiadiazole derivatives was performed via the reaction of dithiocarbamate derivatives and hydrazine sulfate in presence of MgO nanoparticles as heterogeneous catalysts, which were prepared by the sol–gel method
1,3,4-Thiadiazole, 1,3,4-thiadiazine, 1,3,6-thiadiazepane and quinoxaline derivatives from symmetrical hydrazine-1,2-dicarbothioamide as well as N, N″-ethane-1,2-diylbis(thiourea) derivatives
Hassan, Alaa A.,Mourad, Aboul-Fetouh E.,El-Shaieb, Kamal M.,Abou-Zied, Ashraf H.
, p. 471 - 475 (2006)
Reactions of N,N′-disubstituted hydrazine-1,2-carbothioamides 8a-c and substituted N,N″-ethane-1,2-diylbis(thioureas) 9a-c with 2,3,5,6-tetrachloro-1,4-benzoquinone (chloranil, 10a) and 2,3,5,6-tetrabromo-1, 4-benzoquinone (bromanil, 10b) to form N,N′-disubstituted 1,3,4-thiadiazole-2,5-diamines 11a-c, substituted 3-amino-6,7-dichloro-2,3- dihydro-1H-4,2,1-benzothiadiazine-5,8-diones 12a-c, 2,3,7,8- tetrahalothianthrene-1,4,6,9-tetrones 13a,b, substituted 5,6,8-trihalo-7-oxo-3, 7-dihydroquinoxaline-2H-carbothioamides 14a-c, 15a-c and 7-substituted imino-1,3,6-thiadiazepane-2-thiones 16a-c are reported.
Synthesis of Oxa-aza- and Bis-oxathiaaza[33.3]propellanes from Dicyanomethylene-1,3-indanedione and 2,5-Dithiobiureas
Hassan, Alaa A.,Mohamed, Nasr K.,Makhlouf, Maysa M.,Br?se, Stefan,Nieger, Martin
, p. 3036 - 3042 (2015)
An efficient route for the synthesis of oxa-aza- and bis-oxathiaaza[3.3.3]propellanes via reactions of symmetrical and unsymmetrical N1,N2-disubstituted hydrazine-1,2-dicarbothioamides (2,5-dithiobiureas) with (1,3-dioxo-2,3-dihydro-
1,3,4-Thiadiazoles and 1,3-thiazoles from one-pot reaction of bisthioureas with 2-(bis(methylthio)methylene)malononitrile and ethyl 2-cyano-3,3-bis(methylthio)acrylate
Aly, Ashraf A.,Hassan, Alaa A.,Br?se, Stefan,Ibrahim, Mahmoud A. A.,Abd Al-Latif, El-Shimaa S. M.,Spuling, Eduard,Nieger, Martin
, p. 69 - 75 (2017)
Bisthioureas reacted with either 2-(bis(methylthio)methylene)malononitrile or ethyl 2-cyano-3,3-bis(methylthio)acrylate to give 1,3,4-thiadiazoles and 1,3-thiazoles. Only, the reactive allyl derivative of bisthioureas reacted with the bis(methylthio)methy
Design and synthesis of hydrazinecarbothioamide sulfones as potential antihyperglycemic agents
Aly, Ashraf A.,Hassan, Alaa A.,Makhlouf, Maysa M.,Alshammari, Mohammed B.,Mohamed Naguib Abdel Hafez, Sara,Refaie, Marwa M. M.,Br?se, Stefan,Nieger, Martin,Ramadan, Mohamed
, (2021/01/18)
New hydrazinecarbothioamides with a phenylsulfonyl group were synthesized and their structures were identified by different spectroscopic data (1H NMR, 13C NMR, two-dimensional?NMR, mass spectrometry, elemental analysis, and single-crystal X-ray analysis). The mechanism describing the formation of the products was also discussed. The antidiabetic activity of the isolated products was investigated histochemically. The synthesized sulfonylalkylthiosemicarbazide exhibited antihyperglycemic activity in streptozotocin-induced diabetic mice. Compounds?5a and 5c?significantly lowered the blood glucose level to 103.3 ± 1.8 and 102 ± 3.9 mg/dl, respectively. Also, they caused a significant decrease in malondialdehyde levels and normalized the glutathione levels in streptozotocin-induced diabetic mice, compared with the diabetic group. The results suggest that the synthesized hydrazinocarbothioamides may effectively inhibit the development of oxidative stress in diabetes.
Reaction of N,N '-disubstituted hydrazinecarbothioamides with 2-bromo-2-substituted acetophenones
Aly, Ashraf A,Hassan, Alaa A.,Abd Al-Latif, El-Shimaa S. M.,Ibrahim, Mahmoud A. A.,Br?se, Stefan,Nieger, Martin
, p. 102 - 111 (2018/02/07)
Reaction of hydrazinecarbothioamides with 2-bromoacetophenones furnished the formation of thiazole-, bisthiazole-, pyrazole- and 1,3,4-thiadiazole- derivatives in good yields. The mechanism was discussed. The structures of products were proved by MS, IR,
Novel and efficient cyclization procedure for the synthesis of 2,5-disubstituted-1,3,4-thiadiazoles without using any ring-closing reagents
Lin, Qi,Zhang, You-Ming,Li, Man-Lin,Wei, Tai-Bao
, p. 3251 - 3260 (2012/09/10)
A novel method for the synthesis of 2,5-disubstituted-1,3,4-thiadiazoles via direct ring closure of 1,6-disubstituted-2,5-dithioureas in dimethylformanide without using any ring-closing reagents has been accidentally discovered. Repeated and extended experiments confirmed that this is a very simple and efficient way to synthesize these kinds of fine chemicals. A series of novel 2,5-disubstituted-1,3,4-thiadiazoles have been synthesized via this method in good yields.
Desulfurization strategy in the construction of azoles possessing additional nitrogen, oxygen or sulfur using a copper(I) catalyst
Guin, Srimanta,Rout, Saroj Kumar,Gogoi, Anupal,Nandi, Shyamapada,Ghara, Krishna Kanta,Patel, Bhisma K.
, p. 2757 - 2770 (2013/01/15)
A tandem and convergent approach to various N-, O-, or S-containing azoles has been developed by exploiting the thiophilic property of copper( I) iodide used in a catalytic quantity. The present protocol gives access to amino-substituted tetrazoles, triazoles, oxadiazoles and thiadiazoles via oxidative desulfurization of their respective precursors followed by inter- or intramolecular attack of suitable nucleophiles. For aminotetrazoles and triazoles an excellent regioselectivity has been achieved through proper tuning of the pKa values of the parent amines attached to unsymmetrical thioureas. The method represents an autocatalytic process in which copper( I) iodide gets converted to copper(II) sulfide which in turn transforms to active copper(II) oxide that effectively carries forward the catalytic cycle. The fate of the copper catalyst has also been studied using scanning electron microscopic (SEM) and energy-dispersive X-ray spectroscopic (EDS) analyses which give an insight into the mechanism for this catalytic process.
